rs11805334 (PROX1-AS1): RPL31P13 Locus Research
Key takeaways
- rs11805334 is located in the RPL31P13 - PROX1-AS1 region, spanning a ribosomal pseudogene and an antisense RNA locus.
- No specific trait associations, odds ratios, or p-values for this variant are reported in the available research.
- Evidence for this locus is limited and preliminary; no replication data are available from the supplied sources.
- No drug response, tissue expression, or lifestyle data are currently on file for rs11805334.
Key takeaways
- rs11805334 is located in the RPL31P13 - PROX1-AS1 genomic region, which includes a ribosomal protein pseudogene (RPL31P13) and an antisense RNA locus (PROX1-AS1).
- No specific trait associations, odds ratios, or p-values for this variant are reported in the available research text.
- Evidence for any trait association at this locus is preliminary and cannot be evaluated from the supplied material.
- No drug response, tissue expression, or lifestyle data are on file for this variant.
What the research says The sole source covering this variant is a genome-wide association study using Quickdraws, a mixed-model association algorithm applied to approximately 405,088 UK Biobank participants across 79 quantitative and 50 binary traits. The available study text focuses on algorithmic benchmarking and does not include variant-level summary statistics, effect sizes, or p-values for rs11805334, so no specific trait association can be attributed to this locus from the supplied material.
Reported associations
- No trait-specific associations for rs11805334 are described in the provided study text.
Evidence quality The source study analyzed a large cohort (n = 405,088 UK Biobank participants) using a statistically robust framework. However, the available text covers algorithm design and benchmark comparisons between methods (Quickdraws, REGENIE, FastGWA, BOLT-LMM, SAIGE) only; it does not present variant-level results, p-values, or replication data for rs11805334. Without these details, the strength of evidence for any association at this locus cannot be assessed from the supplied material. No independent replication cohorts, conflicting findings, or functional follow-up studies are described in the provided sources.
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What is rs11805334?
rs11805334 is a single-nucleotide polymorphism located near two overlapping genomic features: RPL31P13, a ribosomal protein pseudogene (a DNA sequence resembling a protein-coding gene but not translated into protein), and PROX1-AS1, an antisense RNA gene.
What traits is rs11805334 associated with?
No specific trait associations for rs11805334 are reported in the currently available research. The variant appears in a large UK Biobank dataset used to benchmark a GWAS method, but variant-level results are not included in the provided study text.
What is PROX1-AS1?
PROX1-AS1 is an antisense RNA gene located on the opposite DNA strand from the PROX1 protein-coding gene. Antisense RNAs can regulate the expression of nearby genes, but the functional role of PROX1-AS1 in human traits is not described in the available study.
Was rs11805334 studied in the UK Biobank?
The variant falls within a dataset analyzed by a large-scale GWAS study of approximately 405,088 UK Biobank participants, but the available text does not report specific results for this individual variant.
What does RPL31P13 mean?
RPL31P13 stands for Ribosomal Protein L31 Pseudogene 13. Pseudogenes are genomic sequences that closely resemble functional genes but typically do not produce a working protein. Their proximity to functional genes can still influence nearby gene regulation.