Expressive

rs117908910 (HS6ST3): GWAS Variant Profile

Key takeaways

  • rs117908910 is a genetic variant at the HS6ST3 gene locus, captured in a large-scale UK Biobank genome-wide association study
  • The study included over 405,000 participants and 13.3 million genetic variants across 79 quantitative and 50 binary traits
  • The GWAS method used, Quickdraws, detects up to 22% more associations than older tools applied to the same data
  • No specific trait associations or effect sizes for this variant are reported in the available study text
  • Evidence for rs117908910's biological effects is currently limited based on available sources

Key takeaways

  • rs117908910 is a genetic variant at the HS6ST3 gene locus, captured in a genome-wide association study of over 405,000 UK Biobank participants
  • The study analyzed 13.3 million variants across 79 quantitative and 50 binary traits using a method designed to detect associations that older tools may miss
  • No specific trait associations or effect sizes for this variant appear in the available study text
  • Evidence for the biological effects of rs117908910 is currently limited based on available sources
  • No clinical or lifestyle guidance can be drawn from the current evidence base

What the research says rs117908910, located at the HS6ST3 locus, was among the 13.3 million variants analyzed in a UK Biobank genome-wide association study of 405,088 participants covering 79 quantitative and 50 binary traits. The study applied Quickdraws, a mixed-model association method that uses a spike-and-slab prior (a statistical framework that distinguishes variants with detectable effects from those without, in contrast to simpler methods that assume all variants contribute equally) and stochastic variational inference (an efficient computational optimization technique that scales linearly with sample size), accelerated by GPU hardware. Specific association results for rs117908910 are not reported in the available study text.

Reported associations

  • HS6ST3 locus: No specific trait or disease associations for rs117908910 are detailed in the available study text; the variant was part of a large genome-wide scan but per-variant results are not provided in the available excerpt.

Evidence quality The sole available source is a 2025 Nature Genetics methods paper by Loya H, Kalantzis G, Cooper F, and Palamara PF, demonstrating that Quickdraws identifies 4.97% more quantitative trait associations and 3.25% more binary trait associations than REGENIE, and 22.71% and 7.07% more than FastGWA respectively, across 405,088 UK Biobank participants. While the paper notes that replicated signals were found in Biobank Japan and FinnGen, no specific p-values, odds ratios, or replication data for rs117908910 are given in the available text. Evidence quality for this specific variant cannot be assessed from the provided sources, and must be considered absent or preliminary.

Lifestyle considerations No lifestyle considerations on file for this variant.

Frequently asked questions

What is rs117908910?

rs117908910 is a single-nucleotide polymorphism, a position in the human genome where individuals may carry different DNA letters. It is located at the HS6ST3 gene locus and was included in a large UK Biobank genome-wide association study.

What is the HS6ST3 gene?

HS6ST3 is the gene symbol for the locus where rs117908910 is found. The available studies do not describe the gene's function or the effect of this specific variant on the gene.

Is rs117908910 linked to any diseases or traits?

No specific disease or trait associations for rs117908910 are reported in the available studies. It was captured in a broad genome-wide scan, but detailed per-variant results are not included in the study excerpts available here.

How was rs117908910 identified?

The variant was analyzed using Quickdraws, a genome-wide association method applied to 405,088 UK Biobank participants. Quickdraws uses machine learning techniques including a spike-and-slab statistical prior to detect genetic associations with greater sensitivity than many earlier methods.

What is a genome-wide association study?

A genome-wide association study, or GWAS, scans hundreds of thousands to millions of genetic variants across large groups of people to find positions in the genome statistically linked to traits or diseases. The study involving rs117908910 analyzed over 13 million variants in more than 405,000 participants.