rs117893821 (LINC00656): Biomarker Variant Research
Key takeaways
- rs117893821 is located in the LINC00656 - LINC03125 genomic region, which contains two long intergenic non-coding RNA genes.
- This variant was captured in a large UK Biobank genetic study of 35 blood and urine biomarkers in 363,228 individuals.
- Specific trait associations and effect sizes for rs117893821 are not described in the available study text.
- Evidence for this variant is preliminary, with no detailed replication data or effect size on record here.
Key takeaways
- rs117893821 is located in the LINC00656 - LINC03125 genomic region, which contains two long intergenic non-coding RNA genes.
- This variant was captured in a large UK Biobank genetic study of 35 blood and urine biomarkers in 363,228 individuals.
- Specific trait associations and effect sizes for rs117893821 are not described in the available study text.
- Evidence for this variant is preliminary, with no detailed replication data or effect size on record here.
What the research says rs117893821 falls in a region annotated to LINC00656 and LINC03125, two long intergenic non-coding RNA (lincRNA) genes whose transcripts do not encode proteins. The one study in this record is a genome-wide association analysis of 35 blood and urine clinical biomarkers in 363,228 UK Biobank participants, which identified 1,857 loci associated with at least one biomarker across more than 9 million genetic variants. Specific association results for rs117893821 - including which of the 35 biomarkers it may be linked to and the corresponding effect size - are not contained in the available study excerpt.
Reported associations
- Blood and urine biomarkers (non-specific): The parent study examined 35 clinical laboratory measurements across n=363,228 individuals; which, if any, of those biomarkers rs117893821 is specifically associated with is not stated in the available text.
Evidence quality The parent study is well-powered (n=363,228 unrelated UK Biobank individuals, with meta-analysis in up to n=355,891 across population groups), applied Bonferroni correction across more than 9 million imputed variants (threshold: p < 5 x 10^-9 for assayed and imputed variants), and validated effect sizes against 42 independent cohorts. LD Score regression intercepts fell between 0.999 and 1.137 across all 35 biomarkers, indicating that population structure was well controlled. However, the available study text does not include association data specific to rs117893821, so evidence quality for this variant in particular cannot be assessed. No p-value, effect size, or replication result for this variant is available in the provided text. This entry should be treated as preliminary.
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What is rs117893821?
rs117893821 is a single nucleotide polymorphism (a single-letter change in the DNA sequence) located in the LINC00656 - LINC03125 genomic region. Both LINC00656 and LINC03125 are long intergenic non-coding RNA genes, meaning they produce RNA but not proteins.
What are LINC00656 and LINC03125?
LINC00656 and LINC03125 are long intergenic non-coding RNAs (lincRNAs). These genes are transcribed into RNA molecules that do not carry instructions for building proteins. Their specific biological roles are not well characterized in the available research.
Is rs117893821 associated with any health conditions?
This variant appears in a large UK Biobank study of 35 blood and urine biomarkers, but the specific biomarker associations for rs117893821 are not described in the available research text. No confirmed disease or trait associations are documented in this record.
How large was the UK Biobank biomarker study that included this variant?
The study included 363,228 unrelated UK Biobank individuals and examined over 9 million genetic variants across 35 commonly measured clinical laboratory tests. Effect sizes were validated against 42 independent cohorts.
What does it mean for a variant to sit in a non-coding RNA gene?
Non-coding RNA genes produce RNA molecules that are not translated into proteins. Variants in these regions may influence gene regulation or other cellular processes, but the functional effects of rs117893821 specifically are not described in the available studies.