Expressive

rs117704645 (BDP1P/RNA5SP461): COVID-19 GWAS Variant

Key takeaways

  • This variant lies in a genomic region containing BDP1P, a pseudogene, and RNA5SP461, a small RNA gene
  • It appears in the context of COVID-19 genetic research using UK Biobank data covering up to 18,481 cases
  • Its specific association signal and effect size are not explicitly reported in the available research
  • No confirmed associations or lifestyle links have been established for this variant

Key takeaways

  • This variant lies in a genomic region containing BDP1P (a pseudogene, meaning a gene-like DNA sequence that does not produce a functional protein) and RNA5SP461 (a small structural RNA gene)
  • It appears in the context of COVID-19 genetic research using UK Biobank data covering up to 18,481 cases
  • Its specific association signal and effect size are not explicitly reported in the available research
  • No confirmed associations or lifestyle links have been established for this variant

What the research says A genome-wide association study (GWAS, a method that scans many genetic variants across large populations to find those linked to a trait or disease) using UK Biobank data performed 65 analyses covering COVID-19 susceptibility, hospitalization, severe outcomes, and death, with up to 18,481 susceptibility cases collected through June 2021. The study applied a time-series approach to identify suggestive candidate variants (P < 10-5) that grew in statistical confidence across successive data releases, producing hundreds of signals beyond established loci such as chr3p21.31, ABO, APOE, and DPP9. The rs117704645 locus is not explicitly named or characterized in the available study text.

Reported associations

  • COVID-19-related phenotypes (context only): The study covering this locus examined susceptibility, hospitalization (n = 3,260 cases), severe outcomes (n = 1,244), and death (n = 1,104) as outcome measures; this specific variant is not explicitly named among the reported associations

Evidence quality The sole available source is a UK Biobank COVID-19 GWAS with up to 18,481 susceptibility cases, stratified by sex and ancestry across 65 separate analyses and multiple data releases. Replicated findings from this study center on chr3p21.31 (odds ratio 1.21 for susceptibility and 1.62 for severity at two independent signals), ABO (odds ratio 1.10 for susceptibility), and APOE (associated with severity and death); signals at LRMDA and a chr2q32.3 locus in women did not replicate in independent datasets. Because this locus is not explicitly described in the available study text, its association status, direction of effect, and effect size are unknown. Evidence for any specific association here should be considered absent or at best uncharacterized.

Lifestyle considerations No lifestyle considerations on file for this variant.

Frequently asked questions

What is rs117704645?

rs117704645 is a single-nucleotide polymorphism (a one-letter change in the DNA sequence) located in a region containing BDP1P, a pseudogene, and RNA5SP461, a small RNA gene. It appears in the context of COVID-19 genome-wide association research but has not been explicitly characterized in published study text.

What does BDP1P do?

BDP1P is a pseudogene, meaning a DNA sequence that resembles a functional gene but does not appear to produce a working protein. Its biological role, if any, is not established in the available research.

Is rs117704645 linked to COVID-19?

This variant appears in the context of COVID-19 genome-wide association studies using UK Biobank data, but its specific association with COVID-19 outcomes such as susceptibility, hospitalization, or severity is not explicitly reported in the available study text. No confirmed link can be drawn from current evidence.

What is a genome-wide association study (GWAS)?

A GWAS scans hundreds of thousands of genetic variants across large groups of people to find those statistically linked to a trait or disease. The COVID-19 GWAS providing context for this variant examined up to 18,481 cases but did not explicitly characterize this specific variant among its top findings.

What is RNA5SP461?

RNA5SP461 is a small RNA pseudogene located in the same genomic region as rs117704645 and BDP1P. Its specific biological function has not been characterized in the available study.