rs117689151 (NRXN2): Protein Ratio pQTL Variant
Key takeaways
- rs117689151 near NRXN2 (Neurexin 2) was identified in a proteomics study of more than 54,000 UK Biobank participants
- Analyzing ratios between protein levels found 24.7% more genetic signals than standard single-protein GWAS methods
- Protein ratio associations were 7.6-fold enriched in known protein-protein interactions
- Evidence for this specific variant is preliminary, as detailed effect sizes are not available in the provided source text
Key takeaways
- rs117689151 near NRXN2 (Neurexin 2) was identified in a proteomics study of more than 54,000 UK Biobank participants
- Analyzing ratios between protein levels found 24.7% more genetic signals than standard single-protein GWAS methods
- Protein ratio associations were 7.6-fold enriched in known protein-protein interactions
- Evidence for this specific variant is preliminary, as detailed effect sizes are not available in the provided source text
What the research says A genome-wide association study applying ratio-based analysis to 1,463 blood circulating proteins measured in over 54,000 UK Biobank samples identified 4,248 associations with 2,821 protein pair ratios, called ratio quantitative trait loci (rQTLs). These rQTLs were 7.6-fold enriched in established protein-protein interactions, indicating that protein level ratios capture genuine biological relationships between proteins. Analyzing ratios increased the total number of discovered genetic signals by 24.7% compared to standard single-protein approaches, revealing loci that would otherwise remain below detection thresholds.
Reported associations
- Protein ratio / protein-protein interaction: This locus was identified through ratio-based proteomics GWAS analysis of UK Biobank data (n > 54,000). Specific effect sizes and p-values for this variant are not available in the provided source text.
Evidence quality The study analyzed Olink Explore 1536 proteomics data from more than 54,000 UK Biobank participants, a large and well-characterized population cohort. The rQTL methodology was validated by demonstrating 7.6-fold enrichment in known protein interactions across 4,248 associations from 2,821 protein pairs. However, specific effect sizes, p-values, and independent replication data for rs117689151 are not reported in the available source text. Evidence for this locus should be considered preliminary, originating from a single large study without published replication data for this specific variant.
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What is rs117689151?
rs117689151 is a genetic variant in the NRXN2 (Neurexin 2) region, identified in a large proteomics study of UK Biobank participants. It was found through an approach that analyzes ratios between pairs of blood proteins rather than individual protein levels.
What does NRXN2 do?
The provided study identifies NRXN2 in the context of protein-protein interaction networks detected through blood protein ratio analysis. A functional gene description is not available from the source study text provided.
How reliable is the evidence for rs117689151?
The study used more than 54,000 UK Biobank participants and a methodology validated by 7.6-fold enrichment in known protein interactions. However, specific effect sizes and independent replication for this variant are not available in the source text, so evidence is considered preliminary.
What is a ratio quantitative trait locus (rQTL)?
An rQTL is a genetic variant associated with the ratio of two protein levels in the blood. This approach can reveal genetic effects on protein-protein interactions that are invisible when analyzing single proteins alone.
Is rs117689151 linked to any specific disease?
The provided study focuses on protein-protein interaction networks and proteomics methodology. No disease association for this variant is reported in the available source text.