rs117645650 - MEPE - HSP90AB3P
Magnitude 2.8 · 1 study on file
Reported associations
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A genome-wide study on gene-nutrient interactions for hyperuricemia in a large Korean cohort (KoGES) - Unknown journal (n.d.) · Unknown authors · PubMed 40835619
ABSTRACT: This study aimed to identify novel genetic variants associated with hyperuricemia risk across multiple nutrients by assessing significant gene-nutrient interactions using large-scale genome-wide association study (GWAS) data in the Korean population. A total of 48,007 individuals from the Korean Genome and Epidemiology Study dataset were included in the GWAS. Dietary intake was evaluated using a food frequency questionnaire. To identify genomic loci that interact with specific nutrients influencing hyperuricemia risk, we conducted a GWAS followed by gene-nutrient interaction analyses of genome-wide significant single-nucleotide polymorphisms (SNPs). Two SNPs with significant gene-nutrient interactions for specific nutrients were identified: rs113206751 in the Membrane-Assoc
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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serum uric acid levels Moderate
This variant is associated with hyperuricemia susceptibility; periodic monitoring can detect elevated levels early
Annual check or as recommended by physician
Diet
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ensure adequate dietary cholesterol intake Moderate
Variant carriers show increased hyperuricemia risk with low cholesterol intake; adequate intake may reduce risk
Include sources like eggs, fish, or lean meat in regular diet
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ensure adequate potassium intake Moderate
Variant carriers show increased hyperuricemia risk with low potassium intake; adequate intake may reduce risk
Aim for 2600-3400 mg/day from vegetables, fruits, legumes