rs117498629 (GPAM): Blood Biomarker Variant

Key takeaways

• rs117498629 was found in a genome-wide scan of 363,228 UK Biobank participants studying 35 blood and urine measurements.
• The variant maps to the RPS6P15 - GPAM locus.
• The study identified 1,857 loci and 3,374 fine-mapped associations across all biomarkers tested.
• Specific trait associations and effect sizes for this variant are not detailed in the available research text.

What the research says A large genome-wide association study (GWAS - a scan of millions of genetic variants across the genome to find those linked to a measured trait) of 35 blood and urine biomarkers in the UK Biobank identified 1,857 loci each significantly associated with at least one measurement across 363,228 individuals. rs117498629 was mapped to the RPS6P15 - GPAM locus within this scan, which covered lipid measurements, glycemic traits (related to blood sugar regulation), kidney function tests, liver function tests, and other standard clinical laboratory values. Fine-mapping, a statistical technique used to narrow down the most likely causal variant within an associated chromosomal region, yielded 3,374 total associations genome-wide across the 35 biomarkers.

Reported associations

• Blood or urine biomarker (UK Biobank panel): rs117498629 was captured in a genome-wide scan of 35 clinical laboratory measurements in 363,228 UK Biobank participants; the specific biomarker this variant associates with is not identified in the available study text.

Evidence quality The sole available source is a large-scale UK Biobank GWAS (n=363,228) examining 35 blood and urine biomarkers, applying a Bonferroni-corrected significance threshold of p < 5 x 10^-9 for imputed variants. Heritability across the 35 biomarkers was estimated using both LD Score regression (a method for estimating heritable genetic signal from summary statistics) and the Heritability Estimator from Summary Statistics (HESS) approach. The study population spanned multiple ancestries, including White British (n=318,953), non-British White (n=23,582), African (n=6,019), South Asian (n=7,338), and East Asian (n=1,082) groups, though the East Asian group was not included in the primary meta-analysis. The specific p-value, effect size, and replication status for rs117498629 individually are not reported in the provided study excerpt, and evidence for this variant's precise associations should be considered preliminary.

Lifestyle considerations No lifestyle considerations on file for this variant.