rs117385357 - LINC02498 - MIR572
Magnitude 2.8 · 1 study on file
Reported associations
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A genome-wide study on gene-nutrient interactions for hyperuricemia in a large Korean cohort (KoGES) - Unknown journal (n.d.) · Unknown authors · PubMed 40835619
ABSTRACT: This study aimed to identify novel genetic variants associated with hyperuricemia risk across multiple nutrients by assessing significant gene-nutrient interactions using large-scale genome-wide association study (GWAS) data in the Korean population. A total of 48,007 individuals from the Korean Genome and Epidemiology Study dataset were included in the GWAS. Dietary intake was evaluated using a food frequency questionnaire. To identify genomic loci that interact with specific nutrients influencing hyperuricemia risk, we conducted a GWAS followed by gene-nutrient interaction analyses of genome-wide significant single-nucleotide polymorphisms (SNPs). Two SNPs with significant gene-nutrient interactions for specific nutrients were identified: rs113206751 in the Membrane-Assoc
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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adequate dietary cholesterol Moderate
Low cholesterol intake amplifies hyperuricemia risk in A allele carriers; adequate dietary fat may mitigate this effect.
Include sources of dietary cholesterol (eggs, dairy, fish); aim for 25-35% of calories from fat.
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adequate dietary protein intake Moderate
Low protein intake amplifies hyperuricemia risk in A allele carriers; adequate protein may mitigate this effect.
Aim for at least 0.8g protein per kg body weight daily.
Screening
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serum uric acid level Moderate
A allele carriers have elevated hyperuricemia risk, especially with low protein or cholesterol intake; monitoring enables early detection.
Check baseline serum uric acid; repeat testing annually or as recommended by clinician.