Expressive

rs117215038 (TMEM229A-SSU72L6): UK Biobank GWAS

Key takeaways

  • rs117215038 was analyzed in a genome-wide study of 405,000 people using Quickdraws, a machine-learning method that detects more genetic associations than older tools.
  • The study covered 79 measurable traits and 50 disease conditions across 13.3 million genetic variants.
  • No specific trait associations for this variant are reported in the available study text.
  • Replication of any potential associations in independent cohorts has not been described in the available evidence.

Key takeaways

  • rs117215038, near TMEM229A (transmembrane protein 229A) and SSU72L6, was analyzed as part of a genome-wide association study (a survey of millions of genetic variants across a large population) of approximately 405,000 UK Biobank participants.
  • The study applied a machine-learning method called Quickdraws across 79 measurable traits and 50 disease conditions spanning 13.3 million genetic variants.
  • No specific trait associations for this variant are reported in the available study text, so its biological effects remain uncharacterized from this source.
  • Replication of any potential associations in independent cohorts has not been described in the available evidence.

What the research says rs117215038, located in the TMEM229A - SSU72L6 region, was included in a large-scale genome-wide association study applying the Quickdraws algorithm to 13.3 million genetic variants in approximately 405,088 UK Biobank participants covering 79 quantitative traits and 50 binary disease traits. The Quickdraws method uses a spike-and-slab Bayesian prior on variant effects, which improves detection of associations compared to methods that assume all genetic effects are normally distributed, and was found to identify 4.97% more quantitative-trait associations and 3.25% more binary-trait associations than the REGENIE method. No variant-level results specific to this locus are provided in the available study text.

Reported associations

  • No specific associations reported: The available study text does not describe trait-level results for this variant. The locus falls within the scope of a UK Biobank genome-wide association study covering 79 quantitative and 50 binary traits, but no association statistics, effect sizes, or p-values specific to rs117215038 are provided in the available source.

Evidence quality The sole available source is a methods paper introducing the Quickdraws algorithm, applied to approximately 405,088 UK Biobank individuals across 13.3 million variants and 129 traits in total. While the study reports overall improvements in association detection (4.97% more quantitative-trait associations and 22.71% more than FastGWA for the same trait category), no variant-level data for rs117215038 appear in the available text. No effect sizes, p-values, replication statistics, or functional annotation are available for this specific locus from the provided source. The evidence base is insufficient to characterize associations for this variant at this time.

Lifestyle considerations No lifestyle considerations on file for this variant.

Frequently asked questions

What is rs117215038?

rs117215038 is a genetic variant located near the TMEM229A and SSU72L6 genes. It was included in a large genome-wide association study of the UK Biobank, but specific trait associations for this variant are not reported in the currently available research.

What genes are near rs117215038?

rs117215038 is located near TMEM229A (transmembrane protein 229A) and SSU72L6. Both gene names appear in the variant identifier, but the available research does not describe specific biological roles for these genes in the context of this variant.

What traits is rs117215038 associated with?

Based on available research, no specific trait associations for rs117215038 have been reported. The variant was analyzed as part of a UK Biobank genome-wide association study covering 79 measurable traits and 50 disease conditions, but no variant-level results are described in the available source.

How large was the study that included rs117215038?

The study applied the Quickdraws algorithm to approximately 405,000 UK Biobank participants, analyzing 13.3 million genetic variants across 79 quantitative and 50 binary traits.

What is TMEM229A?

TMEM229A stands for transmembrane protein 229A. The available research does not describe the specific function of this gene or its relationship to any particular disease or trait in the context of this variant.