Expressive

rs117205737 (SNX29-CPPED1): Late-Life Memory Genetics

Key takeaways

  • This variant sits between two genes, SNX29 and CPPED1, and was studied for its potential role in late-life memory.
  • The research came from one of the largest sex-aware genetic studies of memory, with over 27,000 older adults.
  • Males and females were analyzed separately to find genetic effects on memory that differ by sex.
  • Evidence for this specific variant is preliminary, drawn from a single study whose full results section was not available for review.
  • No lifestyle factors have been directly linked to this variant in the reviewed research.

Key takeaways

  • This variant sits between two genes, SNX29 and CPPED1, and was studied for its potential role in late-life memory.
  • The research came from one of the largest sex-aware genetic studies of memory, with over 27,000 older adults.
  • Males and females were analyzed separately to find genetic effects on memory that differ by sex.
  • Evidence for this specific variant is preliminary, drawn from a single study whose full results section was not available for review.
  • No lifestyle factors have been directly linked to this variant in the reviewed research.

What the research says This variant was examined as part of a sex-stratified and sex-interaction genome-wide association study (GWAS) of late-life memory performance. The parent study enrolled 11,942 males and 15,641 females from four cohorts of cognitive aging and Alzheimer's disease research, including 24,216 non-Hispanic White and 3,367 non-Hispanic Black participants. Harmonized memory composite scores were used to enable cross-cohort comparisons, and the broader study identified sex-specific genetic loci, pathways, and genetic correlations related to late-life memory.

Reported associations

  • Late-life memory performance: rs117205737, in the SNX29-CPPED1 region, was examined in a sex-aware GWAS of harmonized memory composite scores across cohorts that included both cognitively healthy older adults and individuals with Alzheimer's disease. Specific effect sizes for this variant are not available in the provided study text.

Evidence quality The study from which this variant is drawn is described as the largest sex-aware genetic study of late-life memory to date, with over 27,000 participants (11,942 males and 15,641 females) across four cognitive aging cohorts including ACT (Adult Changes in Thought), ADNI (Alzheimer's Disease Neuroimaging Initiative), and ROS/MAP/MARS (Religious Orders Study, Memory and Aging Project, Minority Aging Research Study). Harmonized memory composite scores were developed using modern psychometric techniques to standardize measurements across cohorts. The analysis included both sex-stratified GWAS and sex-interaction GWAS approaches. However, specific statistical evidence for rs117205737, including p-values, effect sizes, and replication status, is not present in the provided study text. The study's top-line reported findings highlighted three other sex-specific loci, in the CBLN2, SCHIP1/IQCJ-SCHIP1, and EGL6/TCEANC/OFD1 regions, as the primary genome-wide results. Evidence for rs117205737 should be considered preliminary until further details are available.

Lifestyle considerations No lifestyle considerations on file for this variant.

Frequently asked questions

What is rs117205737?

rs117205737 is a single-nucleotide variant located in a chromosomal region containing the genes SNX29 and CPPED1. It has been examined in a genome-wide study of late-life memory performance in older adults.

What do the SNX29 and CPPED1 genes do?

SNX29 encodes sorting nexin 29, a protein involved in intracellular sorting and trafficking of molecules within cells. CPPED1 encodes a protein with a calcineurin-like phosphoesterase domain. Their specific roles in memory function are not detailed in the available research.

Is rs117205737 linked to Alzheimer's disease or memory decline?

This variant was studied in a cohort that included people with and without Alzheimer's disease, as part of a genome-wide search for memory-related genetic effects. Specific findings for this variant are not available in the provided study text, and any association should be considered preliminary.

Does this variant affect men and women differently?

The study examining this variant was designed to detect genetic effects on memory that differ between males and females. The sex-specific result for this variant specifically is not available in the provided study text.

What cohorts were used to study this variant?

The study drew from four cohorts including ACT (Adult Changes in Thought), ADNI (Alzheimer's Disease Neuroimaging Initiative), and ROS/MAP/MARS (Religious Orders Study, Memory and Aging Project, and Minority Aging Research Study), with a total of more than 27,000 participants.