rs11720452 - SGO1-AS1 - VENTXP7

Magnitude 2.2 · 1 study on file

Reported associations

• Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder - Unknown journal (n.d.) · Unknown authors · PubMed 18711365

  ABSTRACT: To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 × 10-9) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 × 10-8, rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder. FULL TEXT: [INTRO] Recent genome-wide association studies (GWAS) have identified genetic variants that show consistent association with common, complex diseases, such as type 2 diabetes, prostate cancer and Crohn's disease. In many cases, a critical component for success involved combining results and

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