Expressive

rs10994336 - ANK3

Magnitude 2.0 · 2 studies on file

Reported associations

  • Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder - Unknown journal (n.d.) · Unknown authors · PubMed 18711365

    ABSTRACT: To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 × 10-9) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 × 10-8, rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder. FULL TEXT: [INTRO] Recent genome-wide association studies (GWAS) have identified genetic variants that show consistent association with common, complex diseases, such as type 2 diabetes, prostate cancer and Crohn's disease. In many cases, a critical component for success involved combining results and

  • Meta-Analysis of Genome-Wide Association Data of Bipolar Disorder and Major Depressive Disorder - Unknown journal (n.d.) · Unknown authors · PubMed 20351715

    [INTRO] Substantial indirect evidence suggests overlap between bipolar disorder (BIP) and major depressive disorder (MDD). BIP and MDD have in common major depressive episodes with BIP distinguished by the additional presence of manic (bipolar 1) or hypomanic episodes (bipolar 2). Genetic epidemiological and genome-wide linkage studies are also consistent with overlap between genetic risk factors for both disorders. To attempt to identify common genetic risk factors, we conducted a meta-analysis combining data from genome-wide association studies (GWAS) of BIP (4,387 cases and 6,209 controls) and MDD (1,695 cases and 1,761 controls). [INTRO] Ascertainment, diagnostic assessment, genotyping, quality control, and analysis are detailed elsewhere. Both studies were conducted under the appropr

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