rs117129097 - LINC02441 - LINC02369
Magnitude 4.5 · 1 study on file
Reported associations
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LRRTM4 and PCSK5 Genetic Polymorphisms as Markers for Cognitive Impairment in A Hypotensive Aging Population: A Genome-Wide Association Study in Taiwan - Unknown journal (n.d.) · Unknown authors · PubMed 31362389
ABSTRACT: Hypotension can affect cerebral perfusion and worsen cognitive outcomes. The prevalence of low blood pressure (BP) rises with increasing age. To our knowledge, no study has examined the genetic biomarkers for hypotension-related cognitive impairment (CI) yet. Utilizing the population-based genome-wide study of the Taiwan Biobank containing the data of 2533 healthy aging subjects, we found after adjustments for age, sex, education years, and principal components at a suggestive level of 1 × 10−5 that minor alleles of leucine rich repeat transmembrane neuronal 4 (LRRTM4) (rs13388459, rs1075716, rs62171995, rs17406146, rs2077823, and rs62170897), proprotein convertase subtilisin/kexin type 5 (PCSK5) (rs10521467), and the intergenic variation rs117129097 (the nearby gene: TMEM132C
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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hypotension management and cognitive health Moderate
T allele carriers with hypotension have increased cognitive impairment risk; excessive BP lowering may further impair cerebral perfusion.
If SBP <90 or DBP <60 mmHg develops, discuss individual BP targets and symptoms with healthcare provider
Screening
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blood pressure assessment Moderate
rs117129097 T allele carriers have 1.9-fold increased hypotension risk (OR=1.90, p=0.0005), which impairs cerebral perfusion and cognitive function.
Annual blood pressure screening; more frequent if readings show systolic <120 or diastolic <70 mmHg