Expressive

rs117125393 (CYB5AP4-SSTR4): Blood Biomarker Variant

Key takeaways

  • This variant near SSTR4 and CYB5AP4 was identified in a 363,228-person UK Biobank biomarker genetics study
  • It is one of 1,857 loci linked to at least one of 35 measured blood or urine lab values
  • The study applied strict significance thresholds and fine-mapped over 3,000 associations across those loci
  • No lifestyle or drug-response findings are currently available for this specific variant
  • The specific biomarker trait associated with this variant is not identified in the available study excerpt

Key takeaways

  • This variant, located near the CYB5AP4 and SSTR4 genes, was identified as a significant locus in a genome-wide association study of 35 blood and urine biomarkers
  • The study included 363,228 individuals from the UK Biobank, one of the largest biomarker genetics analyses published to date
  • This locus is one of 1,857 genomic regions found to be associated with at least one of 35 measured laboratory biomarkers in that analysis
  • No lifestyle, supplement, or drug-response data for this variant is available in the provided research
  • Evidence is drawn from a single large-scale study; independent replication for this specific locus is not reported in the available study excerpt

What the research says A genome-wide association study of 35 blood and urine biomarkers in the UK Biobank (n = 363,228 unrelated individuals) identified 1,857 loci associated with at least one of the measured traits, with the CYB5AP4 - SSTR4 region among those implicated. The study used stringent Bonferroni-corrected significance thresholds (p < 5 x 10^-9) for single-variant associations and fine-mapped 3,374 associations within those loci, analyzing five population groups including White British, non-British White, African, South Asian, and East Asian participants. The specific biomarker trait linked to rs117125393 at this locus, and its effect size, are not detailed in the study excerpt provided.

Reported associations

  • Blood or urine biomarker (unspecified): rs117125393 at the CYB5AP4 - SSTR4 locus was identified in a UK Biobank genome-wide association study (n = 363,228) examining 35 blood and urine laboratory measurements; the particular biomarker it is linked to is not described in the available study excerpt (Sinnott-Armstrong et al., Nature Genetics, 2021).

Evidence quality The evidence for this locus comes from a single genome-wide association study (Sinnott-Armstrong et al., Nature Genetics, 2021) using data from 363,228 UK Biobank participants across five ancestry groups. The study applied Bonferroni-corrected p-value thresholds (p < 5 x 10^-9) and conducted fine-mapping, identifying 3,374 associations across 1,857 loci for 35 biomarkers. The specific p-value, effect size, and biomarker trait for rs117125393 are not reported in the provided study excerpt, limiting assessment of this variant's individual evidence strength. Because only one study is available and the variant-level data is absent from the excerpt, this evidence should be considered preliminary. No conflicting findings are present in the provided study materials.

Lifestyle considerations No lifestyle considerations on file for this variant.

Frequently asked questions

What is rs117125393?

rs117125393 is a genetic variant located near the CYB5AP4 and SSTR4 genes. It was identified in a large genome-wide association study of 35 blood and urine biomarkers conducted in the UK Biobank.

Which biomarker is rs117125393 associated with?

The variant was flagged as significant in a UK Biobank study of 35 blood and urine biomarkers, but the specific biomarker it is linked to is not described in the available study excerpt. The study examined biomarkers including lipids, glycemic traits, kidney function tests, and liver function tests, among others.

How large was the study that identified this variant?

The study analyzed 363,228 unrelated individuals from the UK Biobank across five ancestry groups. It identified 1,857 significant loci and fine-mapped 3,374 associations across 35 laboratory biomarkers.

Is rs117125393 linked to any disease?

The provided research linked this region to blood or urine biomarker levels rather than directly to a disease. The broader study used Mendelian Randomization to explore causal relationships between biomarkers and 40 medically relevant conditions, but specific findings for this locus are not described in the available text.

How reliable is the evidence for rs117125393?

Evidence comes from a single large-scale study with stringent statistical thresholds and a sample of over 363,000 individuals. Because the variant-level data for this specific locus is not detailed in the available excerpt, and no independent replication is reported, the findings should be considered preliminary.