rs117098085 (HLA-DQA1): Allergen Component Sensitization
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Key takeaways
- This variant is linked to higher risk of allergen component sensitization with a reported effect size of 5.72 and p=2e-8 in about 564 people
- The association is based on the T allele which appears more often in those sensitized individuals
- HLA-DQA1 is the gene at this locus
Key takeaways This variant is linked to higher risk of allergen component sensitization with a reported effect size of 5.72 and p=2e-8 in about 564 people The association is based on the T allele which appears more often in those sensitized individuals HLA-DQA1 is the gene at this locus
What the research says This variant is associated with allergen component sensitization (Hevea brasiliensis 8) with a reported effect size of 5.72 and p=2e-8 in about 564 individuals PMID 37780799
Reported associations Allergen component sensitization this variant is linked to higher risk of sensitization with a reported effect size of 5.72 and p=2e-8 PMID 37780799
Evidence quality The study reports a strong association in about 564 individuals with an effect size of 5.72 and p=2e-8 PMID 37780799 but does not report replication. No lifestyle considerations on file for this variant.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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Latex exposure Moderate
HLA-DQA1 gene variants impair immune tolerance to natural rubber latex proteins, increasing allergic sensitization risk.
Use latex-free gloves, condoms, and medical devices. Inform healthcare providers of genetic latex allergy risk.
Frequently asked questions
What does rs117098085 mean?
It is a genetic variant in the HLA-DQA1 gene that has been linked to higher risk of reacting to plant allergens based on a study with an effect size of 5.72 and p=2e-8.
Is this variant harmful?
The association suggests it may increase susceptibility but does not cause disease by itself.
Can I change my HLA-DQA1?
No, HLA genes are inherited and cannot be changed.