rs11692441 (LINC01876): BMI and Vegetable Intake GWAS
Key takeaways
- rs11692441 lies near LINC01876, a long non-coding RNA gene that does not produce protein
- The variant has been examined in a genome-wide study of vegetable consumption and BMI in Japanese adults
- Available evidence is from a single study and lacks independent replication
- No confirmed effect size or direction of association is available from the provided study materials
Key takeaways
- rs11692441 is located near LINC01876, a long non-coding RNA gene (a gene that produces RNA but no protein)
- The only available study is a genome-wide association study of vegetable intake frequency and BMI or obesity in Japanese adults (n = 12,225)
- Direct results for rs11692441 are not present in the provided study text, which was truncated before the results section
- Evidence is preliminary and limited to a single, population-specific study with no replication data available
What the research says A genome-wide association study (GWAS, a method that screens hundreds of thousands of genetic variants simultaneously) examined whether specific single nucleotide polymorphisms (SNPs, single-letter DNA changes at fixed positions in the genome) interact with vegetable intake frequency to affect BMI or obesity in Japanese adults recruited from a direct-to-consumer genetic testing service. The study enrolled 12,225 participants aged 18-90 years, with a mean BMI of 23.9 kg/m2 in men and 22.1 kg/m2 in women, and obesity (defined as BMI of 25.0 or higher) prevalences of 32.3% and 17.3%, respectively. The provided study text is truncated within the methods section and does not include any results section data, so whether rs11692441 or the LINC01876 locus reached genome-wide significance in any of this study's analyses cannot be confirmed from the available materials.
Reported associations
- BMI and obesity (vegetable intake interaction context): The study tested genome-wide interactions between the intake frequency of six vegetables (carrot, broccoli, spinach, green vegetables, pumpkin, and cabbage) and both continuous BMI and binary obesity status across all genotyped SNPs; whether rs11692441 appears among the reported findings cannot be verified from the truncated study text provided.
Evidence quality Evidence quality for rs11692441 is very low. Only one study was provided, its full text was truncated before the results section appeared, and no effect size, p-value, confidence interval, or association direction for this specific variant can be confirmed from the available materials. The study population consisted of self-selected users of a Japanese direct-to-consumer genetic testing service (HealthData Lab), which may not be representative of broader populations. No independent replication data are present in the provided studies, and the findings of the underlying GWAS have not been validated against the specific variant of interest here.
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What is LINC01876?
LINC01876 is a long non-coding RNA gene, meaning it produces RNA molecules that are not translated into protein. Long non-coding RNAs are thought to help regulate the activity of nearby genes, but the specific biological role of this locus in relation to body weight or diet is not characterized in the provided study materials.
What is rs11692441 associated with?
rs11692441 has been investigated in the context of a genome-wide study examining genetic interactions between vegetable intake frequency and body mass index or obesity in Japanese adults. Direct association results for this specific variant are not available in the provided study text.
Is rs11692441 linked to obesity or body weight?
The variant appears in a study that used a genome-wide approach to find SNPs modifying the relationship between vegetable consumption and BMI or obesity. However, no confirmed association with effect size or statistical significance for rs11692441 specifically can be stated from the available materials.
How was this variant studied?
It was examined in a genome-wide association study of 12,225 Japanese adults who self-reported vegetable intake frequency across six vegetable types and provided body weight data. The study searched across the entire genome for variants that interact with diet to influence BMI or the likelihood of obesity.
How reliable is the evidence for rs11692441?
Evidence quality is currently very low. Only a single study was available, its full results text was not provided, and no independent replication data exist in the provided materials. Findings should be regarded as preliminary.