rs116910509 - ADAMTSL1: thinner retinal nerve fibre layer
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Key takeaways
- This variant is linked to thinner retinal nerve fibre layer
- The effect size is 3.41 and the p-value is 2e-6
- The study used about 3000 individuals
Key takeaways This variant is linked to thinner retinal nerve fibre layer The effect size is 3.41 and the p-value is 2e-6 The study used about 3000 individuals
What the research says This variant is associated with thinner retinal nerve fibre layer in a genome-wide association study of about 3000 individuals [PMID 38365752]. The reported effect size is 3.41 and the p-value is 2e-6 [PMID 38365752].
Reported associations Retinal nerve fibre layer thickness this variant is linked to thinner RNFL in a genome-wide association study of about 3000 individuals with an effect size of 3.41 and p=2e-6 [PMID 38365752].
Evidence quality The study used about 3000 individuals and reported a small but significant association with the variant [PMID 38365752]. No other studies are provided so replication is not addressed.
No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs116910509 mean?
rs116910509 is a single nucleotide change in the ADAMTSL1 gene that has been associated with thinner retinal nerve fibre layer.
Is this variant linked to eye disease?
The study shows an association between the variant and thinner RNFL which can affect vision but does not cause disease by itself.
Can I get a health report from this?
Consumer DNA tests may include this variant in their reports but they do not diagnose conditions.