rs11680788 (LINC00486): Allergic Rhinitis Variant

Key takeaways

• rs11680788 lies within LINC00486, a long intergenic non-coding RNA, and was identified as a candidate locus in a genome-wide study of allergic rhinitis
• The originating study enrolled 5,633 ethnically diverse North American subjects and found distinct genetic signals in Latino participants versus the full multi-ethnic sample
• Genetic loci in this region co-cluster with a coexpression module enriched 8.6-fold for mitochondrial pathway genes in allergy-relevant immune cells
• Evidence is preliminary: findings are from a single study, no independent replication cohort is described, and the specific P-value and effect size for rs11680788 were not reported in the available study text

What the research says A GWAS of allergic rhinitis in 5,633 ethnically diverse North American subjects identified LINC00486 (rs11680788) among 22 loci achieving P ≤ 1×10^-6, with 4 loci reaching genome-wide significance (P < 5×10^-8) among Latinos and 1 in the full meta-analysis. The study integrated GWAS findings with gene expression data from peripheral blood CD4+ lymphocytes (immune cells central to allergic inflammation), showing that 6 of those 22 loci fell within a single coexpression module - a group of genes whose activity rises and falls together across samples - with a 4.0-fold enrichment (P = 0.0029); this same module was also the top hit for allergic rhinitis-associated expression SNPs (eSNPs; genetic variants correlated with differences in how strongly a nearby gene is expressed), with 3.4-fold enrichment (P = 2.6×10^-²^4). Pathway analysis revealed that the module was enriched 8.6-fold for mitochondrial gene sets (P = 4.5×10^-7²), implicating mitochondrial biology as a candidate mechanism in allergic rhinitis pathogenesis.

Reported associations

• Allergic rhinitis: rs11680788 in LINC00486 is among 22 loci reaching P ≤ 1×10^-6 in a multi-ethnic GWAS of 5,633 North American subjects; the specific odds ratio or effect size for this individual variant was not reported in the available study text
• CD4+ lymphocyte gene expression (eSNP signal): the broader locus cluster to which this variant belongs shows 3.4-fold enrichment for expression SNPs in peripheral blood CD4+ T cells (P = 2.6×10^-²^4)
• Mitochondrial pathway co-expression: the coexpression module containing this locus is enriched 8.6-fold for mitochondrial pathway genes (P = 4.5×10^-7²)

Evidence quality The study enrolled 5,633 ethnically diverse North American subjects - a moderate sample size for a GWAS of a common complex trait. The variant rs11680788 falls within a set of 22 loci at P ≤ 1×10^-6; the stricter genome-wide significance threshold (P < 5×10^-8) was met by 4 loci in Latinos and 1 in the multi-ethnic meta-analysis, but the available text does not specify whether rs11680788 itself crossed that threshold. No individual effect size (odds ratio or beta coefficient) for this variant is reported in the provided excerpt. No independent replication cohort is described, making all findings preliminary. The coexpression module and pathway enrichment statistics characterize the 6-locus module as a whole, not rs11680788 in isolation. The ethnicity-specific signal pattern (Latino vs. multi-ethnic) underscores the importance of diverse representation in any future replication work.

Lifestyle considerations No lifestyle considerations on file for this variant.