Expressive

rs11680012 - LRRFIP1

Magnitude 2.2 · 2 studies on file

Reported associations

  • A variant in the LRRFIP1 gene is associated with adiposity and inflammation. - Obesity (Silver Spring, Md.) (2013) · Plourde M, Vohl MC, Bellis C, Carless M, Dyer T, Dolley G, Marette A, Després JP, Bouchard C, Blangero J, Pérusse L · PubMed 23505185

    Inflammation is an important factor linking abdominal obesity with insulin resistance and related cardiometabolic risk. A genome-wide association study of adiposity-related traits performed in the Quebec Family Study (QFS) revealed that a single-nucleotide polymorphism (SNP) in the LRRFIP1 gene (rs11680012) was associated with abdominal adiposity (P = 4.6 × 10(-6)). The objective of this study was to assess the relationship between polymorphisms in LRRFIP1 gene and adiposity (BMI, fat mass (FM), waist circumference (WC), and computed tomography-derived areas of total, subcutaneous and visceral abdominal adipose tissue) and markers of inflammation (C-reactive protein (CRP) and interleukin-6 (IL-6)). Using Sequenom, 16 tag SNPs in the LRRFIP1 gene, capturing 78% of the genetic variation, we

  • Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits - Unknown journal (n.d.) · Unknown authors · PubMed 33603002

    ABSTRACT: Genome-wide association studies (GWAS) have identified thousands of genetic loci associated with cross-sectional blood pressure (BP) traits; however, GWAS based on longitudinal BP have been underexplored. We performed ethnic-specific and trans-ethnic GWAS meta-analysis using longitudinal and cross-sectional BP data of 33,720 individuals from five cohorts in the US and one in Brazil. In addition to identifying several known loci, we identified thirteen novel loci with nine based on longitudinal and four on cross-sectional BP traits. Most of the novel loci were ethnic- or study-specific, with the majority identified in African Americans (AA). Four of these discoveries showed additional evidence of association in independent datasets, including an intergenic variant (rs4060030, p 

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • metabolic syndrome and type 2 diabetes risk assessment Moderate

    LRRFIP1 variant links abdominal adiposity and inflammation to insulin resistance and cardiometabolic risk

    Discuss with physician; may warrant earlier or more frequent screening than standard population guidelines

Lifestyle

  • anti-inflammatory dietary pattern Moderate

    rs11680012 is linked to elevated CRP; anti-inflammatory diet may help mitigate inflammation-associated cardiometabolic risk

    Adopt Mediterranean or DASH diet pattern; emphasize whole grains, vegetables, fatty fish, olive oil

Screening

  • C-reactive protein (CRP) and inflammatory markers Moderate

    rs11680012 is associated with significantly elevated CRP levels, indicating increased systemic inflammation

    Discuss baseline and periodic CRP testing with physician

  • abdominal adiposity and waist circumference Moderate

    rs11680012 rare allele carriers show approximately 30% greater abdominal adiposity and 75% higher CRP

    Measure waist circumference; discuss inflammatory marker testing with physician

  • diastolic blood pressure Moderate

    rs11680012 associated with increased diastolic blood pressure in large GWAS

    Get blood pressure checked annually or per physician guidelines