rs11655237 - LINC00511

Magnitude 2.8 · 1 study on file

Reported associations

• Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer - Unknown journal (n.d.) · Unknown authors · PubMed 26098869

  [INTRO] Introductory Paragraph [INTRO] Pancreatic cancer is the fourth leading cause of cancer death in the developed world. Both inherited high-penetrant mutations in BRCA2, ATM, PALB2, BRCA1, STK11, CDKN2A and mismatch repair genes as well as low-penetrant loci are associated with increased risk. To identify novel loci, we performed a genome-wide association study on 9,925 pancreatic cancer cases and 11,569 controls, including 4,164 newly genotyped cases and 3,792 controls in 9 studies from North America, Central Europe and Australia. Three newly associated regions were identified: 17q25.1 (LINC00673, rs11655237, OR=1.26, 95%CI:1.19-1.34, P=1.42×10−14), 7p13 (SUGCT, rs17688601, OR=0.88, 95%CI:0.84-0.92, P=1.41×10−8), and 3q29 (TP63, rs9854771, OR=0.89, 95%CI:0.85-0.93, P=2.3

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.