rs116429934 - CSMD1
Magnitude 4.5 · 1 study on file
Reported associations
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Genome-wide association study meta-analysis of blood pressure traits and hypertension in sub-Saharan African populations: an AWI-Gen study - Unknown journal (n.d.) · Unknown authors · PubMed 38104120
ABSTRACT: Most hypertension-related genome-wide association studies (GWASs) focus on non-African populations, despite hypertension (a major risk factor for cardiovascular disease) being highly prevalent in Africa. The AWI-Gen study GWAS meta-analysis for blood pressure (BP)-related traits (systolic and diastolic BP, pulse pressure, mean-arterial pressure and hypertension) from three sub-Saharan African geographic regions (N = 10,775), identifies two novel genome-wide significant signals (p < 5E-08): systolic BP near P2RY1 (rs77846204; intergenic variant, p = 4.95E-08) and pulse pressure near LINC01256 (rs80141533; intergenic variant, p = 1.76E-08). No genome-wide signals are detected for the AWI-Gen GWAS meta-analysis with previous African-ancestry GWASs (UK Biobank (Africa
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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Dietary sodium intake Moderate
High sodium intake elevates blood pressure; particularly important for those with genetic predisposition to elevated blood pressure
Limit to less than 2.3 grams sodium per day
Exercise
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Aerobic exercise for blood pressure management Moderate
Aerobic exercise reduces blood pressure; particularly important given genetic predisposition to elevated mean arterial pressure
150 minutes per week of moderate-intensity activity
Screening
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Blood pressure monitoring Moderate
This SNP is associated with higher mean arterial pressure, increasing blood pressure-related disease risk
Check blood pressure at least annually; discuss baseline assessment if not yet done