rs116392971 (LPP): Genetic Variant Research
Key takeaways
- rs116392971 is a genetic variant at the LPP locus.
- Available research covers a GWAS methods study applied to 405,088 UK Biobank individuals across 79 quantitative and 50 binary traits.
- No specific trait associations for this variant are documented in the provided research.
- Evidence for variant-level effects requires dedicated results not present in the current source set.
Key takeaways
- rs116392971 is a genetic variant at the LPP locus, studied as part of large-scale biobank genome-wide association research.
- The sole research source provided is a methods paper describing the Quickdraws GWAS algorithm, applied to 405,088 UK Biobank individuals across 79 quantitative and 50 binary traits.
- No specific association statistics, effect sizes, or trait links for rs116392971 are reported in the provided study.
- Large-scale GWAS methods continue to expand the power to detect associations at loci such as LPP across complex traits.
What the research says The provided literature describes Quickdraws, a scalable genome-wide association study (GWAS) algorithm that uses a spike-and-slab prior (a statistical model that allows for a mix of variants with no effect and variants with meaningful effects) applied to 13.3 million variants in 405,088 UK Biobank individuals across 79 quantitative and 50 binary traits. Quickdraws was reported to identify 4.97% more quantitative trait associations and 3.25% more binary trait associations than the REGENIE method, with gains in replicated signals also observed in Biobank Japan and FinnGen cohorts. The provided study text does not report specific findings for rs116392971 or the LPP locus.
Reported associations
- No specific trait associations reported: The provided study is a GWAS methods paper and does not document variant-level findings for rs116392971 in the available text.
Evidence quality The sole provided study has no PMID listed in its metadata and is a methodology paper focused on the Quickdraws GWAS algorithm as applied to UK Biobank data (n=405,088). The paper does not report variant-specific findings for rs116392971. No p-values, odds ratios, beta coefficients, or replication data for this locus are available from the provided literature. Evidence for any specific trait association at this variant must be considered absent from this source set, and any association claims would require dedicated study results not present here.
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What is rs116392971?
rs116392971 is a genetic variant at the LPP gene locus, studied as part of large-scale genome-wide association research. The provided research literature does not report specific trait associations for this variant.
What gene is rs116392971 associated with?
rs116392971 is associated with the LPP gene locus.
What traits or conditions is rs116392971 linked to?
No specific trait associations for rs116392971 are documented in the research literature provided for this entry.
How are variants like rs116392971 studied?
Large-scale genome-wide association studies using methods applied to hundreds of thousands of biobank participants analyze millions of variants simultaneously. Tools like Quickdraws have improved the power to detect associations at loci across quantitative and binary traits.