Expressive

rs11638321 (ADAMTS7): Genetic Variant Overview

Key takeaways

  • No trait associations for rs11638321 are reported in the provided studies.
  • The available study examined lung function in smokers and does not address the ADAMTS7 gene.
  • No effect sizes or risk estimates can be drawn from the supplied literature.

Key takeaways

  • The provided studies contain no data on rs11638321 or the ADAMTS7 gene.
  • The single supplied study examined spirometric lung function measures in smokers and does not address this variant.
  • No trait associations, effect sizes, or risk estimates can be reported from the available literature.

What the research says The sole study provided is a genome-wide association study of post-bronchodilator FEV1 (forced expiratory volume in one second, a measure of how much air can be exhaled quickly) and FEV1/FVC ratio (a measure of airflow obstruction) in 13,532 current and former smokers across the COPDGene, ECLIPSE, and GenKOLS cohorts. That study identified risk loci near CHRNA3/5, HHIP, TGFB2, DBH, FAM13A, MMP3/12, and RIN3 but did not examine or report any findings for rs11638321 or the ADAMTS7 gene.

Reported associations

  • No associations with this variant or gene are documented in the provided studies.

Evidence quality The available study enrolled 13,532 smokers and reached genome-wide significance at several loci for spirometric traits. This variant was not examined or reported in that study. No p-values, odds ratios, or replication data for rs11638321 can be extracted from the supplied literature, and evidence quality for this variant cannot be assessed.

Lifestyle considerations No lifestyle considerations on file for this variant.

Frequently asked questions

What is rs11638321?

rs11638321 is a single nucleotide polymorphism - a common type of single-letter DNA variation - located near the ADAMTS7 gene. The studies provided for this entry do not report any specific trait associations for this variant.

What gene does rs11638321 affect?

rs11638321 is catalogued near the ADAMTS7 gene. No functional or association data for this specific variant is present in the provided literature.

Is rs11638321 linked to any disease?

The provided studies do not report any association between rs11638321 and any disease or health outcome. No disease linkage can be confirmed from the available evidence.