Expressive

rs116191209 (CSF1-AHCYL1): UK Biobank GWAS Variant

Key takeaways

  • rs116191209 sits at the CSF1-AHCYL1 locus and was analyzed in a UK Biobank GWAS of about 405,000 individuals
  • The study covered 79 quantitative traits and 50 binary disease traits using a machine-learning-powered association method
  • Specific trait associations and effect sizes for this variant are not reported in the available study text
  • Genome-wide signals from this analysis were assessed for replication in Biobank Japan and FinnGen cohorts

Key takeaways

  • rs116191209 is a variant at the CSF1-AHCYL1 locus, analyzed as part of a large-scale UK Biobank genome-wide association study (GWAS) of approximately 405,000 individuals
  • The source study scanned 79 quantitative traits and 50 binary disease traits across 13.3 million variants
  • Specific trait associations and effect sizes for this particular variant are not detailed in the available study text
  • The analysis used the Quickdraws mixed-model method, which identified substantially more genome-wide associations than prior tools such as REGENIE and FastGWA

What the research says A large-scale GWAS using the Quickdraws mixed-model association method analyzed 13.3 million variants in approximately 405,088 UK Biobank individuals across 79 quantitative and 50 binary traits. Quickdraws identified 4.97% more associations than REGENIE and 22.71% more than FastGWA for quantitative traits, and 3.25% and 7.07% more, respectively, for binary traits. Specific association data for rs116191209 at this locus is not reported in the available text of the source study.

Reported associations

  • UK Biobank GWAS analysis: This variant was among those analyzed across approximately 405,000 participants covering 79 quantitative and 50 binary trait analyses; no specific effect size or trait association for this variant is provided in the available study text

Evidence quality The source study represents a large-scale analysis covering approximately 405,088 UK Biobank samples, with genome-wide signals assessed for replication in external cohorts including Biobank Japan and FinnGen. However, specific p-values, effect sizes, and replication status for rs116191209 are absent from the available study excerpt, making it impossible to characterize the evidence quality for this particular variant. This absence of variant-specific data is a significant limitation of the current entry.

Lifestyle considerations No lifestyle considerations on file for this variant.

Frequently asked questions

What is rs116191209?

rs116191209 is a genetic variant located at the CSF1-AHCYL1 locus. It was analyzed as part of a large genome-wide association study of approximately 405,000 UK Biobank participants.

What genes are near rs116191209?

rs116191209 is located near the CSF1 and AHCYL1 genes. The available study does not detail which gene is most directly influenced by this variant.

What traits is rs116191209 linked to?

The available research analyzed rs116191209 as part of a scan of 79 quantitative and 50 binary traits in UK Biobank participants. Specific association data for this variant is not reported in the available study text.

How was rs116191209 identified?

This variant was analyzed using Quickdraws, a mixed-model association method that uses machine learning and GPU acceleration to increase statistical power. The method was applied by Loya and colleagues to approximately 405,000 UK Biobank participants.

Is rs116191209 replicated in other populations?

The Quickdraws study assessed replication of genome-wide signals in Biobank Japan and FinnGen, but variant-specific replication data for rs116191209 is not available in the provided study text.