rs1155675 (LINC02409): Educational Attainment

Key takeaways

• rs1155675 near LINC02409 is one of 3,952 variants tied to years of schooling in a study of approximately 3 million people
• A polygenic score combining all significant variants explains 12 to 16 percent of variation in educational attainment
• Direct genetic effects account for roughly half the polygenic score's predictive power when parental genetics are controlled
• No dominance effects (non-additive inheritance) were detected across 2.5 million people, suggesting the variant acts additively
• LINC02409 is a long intergenic non-coding RNA; its biological role in educational attainment is not described in the available research

What the research says rs1155675 maps near LINC02409 (long intergenic non-coding RNA 02409, a segment of DNA that is copied into RNA but does not instruct cells to make a protein) and Y_RNA, and was identified as one of 3,952 approximately independent genome-wide-significant single-nucleotide polymorphisms (SNPs - single-letter DNA variants at a fixed position in the genome) associated with educational attainment in a meta-analysis of approximately 3,037,499 individuals. A genome-wide polygenic index (a score that aggregates small effects across thousands of variants into a single number) constructed from these SNPs explains 12 to 16 percent of the variance in years of schooling completed, depending on the validation sample, representing roughly a 20 percent improvement over the prior-generation score. When parental polygenic indexes are statistically controlled in within-family analyses, direct genetic effects account for roughly half the polygenic index's total association with educational attainment and related phenotypes, indicating that a substantial portion of the signal reflects indirect pathways such as gene-environment correlation.

Reported associations

• Educational attainment (years of schooling): rs1155675 is among 3,952 approximately uncorrelated genome-wide-significant SNPs in a meta-analysis of approximately 3,037,499 individuals; the combined polygenic predictor explains 12-16% of variance in years of schooling (mean chi-squared statistic across included SNPs: 4.90; prior-generation predictor explained 11-13%)

Evidence quality This locus was identified in a meta-analysis of approximately 3,037,499 individuals, one of the largest genetic association studies of any complex trait conducted to date. The combined polygenic index from all 3,952 significant variants explains 12 to 16 percent of variance in educational attainment across validation samples. A dominance GWAS (testing non-additive genetic effects, where carrying two copies of a variant differs from twice the single-copy effect) in 2,574,253 individuals identified no genome-wide-significant SNPs, and the study states high confidence that no common SNP dominance effect explains more than a negligible fraction of educational attainment variance. No individual effect size (beta coefficient or odds ratio) for rs1155675 specifically is reported in the available study text. Independent replication of this specific signal is not described in the provided material, and the biological mechanism linking LINC02409 or Y_RNA to educational attainment is not addressed in the available study.

Lifestyle considerations No lifestyle considerations on file for this variant.