rs11546569 (GCNT1): Large UK Biobank GWAS Variant
Key takeaways
- Analyzed in one of the largest genetic studies to date, covering approximately 405,088 UK Biobank participants
- rs11546569 is a variant in the GCNT1 gene region
- Part of a genome-wide scan of 13.3 million variants across 129 complex traits
- Specific trait associations for this variant are not detailed in the available study text
Key takeaways
- Analyzed in one of the largest genetic studies to date, covering approximately 405,088 UK Biobank participants
- rs11546569 is a genetic variant in the GCNT1 gene region
- Part of a genome-wide scan of 13.3 million variants across 129 complex traits
- Specific trait associations for this variant are not detailed in the available study text
What the research says rs11546569, located in the GCNT1 gene region, was analyzed as part of a large-scale genome-wide association study (GWAS - a method for scanning across the entire genome to find variants statistically linked to traits) applying the Quickdraws method to approximately 405,088 UK Biobank participants across 79 quantitative traits and 50 binary (disease) traits. The study scanned 13.3 million variants in total and identified 4.97% more quantitative trait associations and 3.25% more binary trait associations compared to the widely used REGENIE method, with results replicated in Biobank Japan and FinnGen. Specific association data for this individual variant are not detailed in the available study text.
Reported associations
- Not specified in available text: rs11546569 was among 13.3 million variants analyzed across 129 traits in 405,088 UK Biobank participants; no variant-specific association results are reported in the available study text
Evidence quality The available study describes a large-scale GWAS methodology applied to 405,088 UK Biobank participants, analyzing 13.3 million variants across 79 quantitative and 50 binary traits. The Quickdraws method used in this analysis was designed to maximize statistical power while remaining computationally efficient, and discovered associations were replicated in Biobank Japan and FinnGen cohorts. However, variant-level association statistics, effect sizes, and p-values specific to rs11546569 are not present in the provided study text, limiting assessment of this variant's specific evidence base.
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What is rs11546569?
rs11546569 is a single nucleotide polymorphism (a single-letter difference in DNA between individuals) located in the region of the GCNT1 gene. It was among over 13 million variants analyzed in a large UK Biobank genome-wide association study of approximately 405,088 participants.
What is the GCNT1 gene?
GCNT1 is the gene associated with rs11546569. The available study text does not detail the specific biological function or trait associations of this gene.
What traits is rs11546569 associated with?
The available study text does not report specific trait associations for rs11546569. It was included in a GWAS covering 79 quantitative traits and 50 binary disease traits in UK Biobank participants.
How reliable is the evidence for rs11546569?
The available study applied a high-powered method called Quickdraws to a large sample of approximately 405,088 UK Biobank participants, with associations replicated in Biobank Japan and FinnGen. However, variant-specific statistics for rs11546569 are not available in the current study text.