rs115455482 - CHRM3
Magnitude 2.2 · 1 study on file
Reported associations
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A regulatory variant of CHRM3 is associated with cannabis-induced hallucinations in European Americans - Unknown journal (n.d.) · Unknown authors · PubMed 31740666
ABSTRACT: Cannabis, the most widely used illicit drug, can induce hallucinations. Our understanding of the biology of cannabis-induced hallucinations (Ca-HL) is limited. We used the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) to identify cannabis-induced hallucinations (Ca-HL) among long-term cannabis users (used cannabis ≥1 year and ≥100 times). A genome-wide association study (GWAS) was conducted by analyzing European Americans (EAs) and African Americans (AAs) in Yale-Penn 1 and 2 cohorts individually, then meta-analyzing the two cohorts within population. In the meta-analysis of Yale-Penn EAs (n = 1917), one genome-wide significant (GWS) signal emerged at the CHRM3 locus, represented by rs115455482 (P = 1.66 × 10−10), rs74722579 (P = 2.
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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Long-term cannabis use Moderate
T allele associated with reduced CHRM3 expression in thalamus, increasing susceptibility to cannabis-induced hallucinations
Avoid regular long-term cannabis use; if using, monitor for hallucinations and consider cessation