rs115417878 (ARHGEF11): What Research Shows
Key takeaways
- rs115417878 sits in the ARHGEF11 gene region.
- A 405,000-person UK Biobank GWAS using the Quickdraws method covered this gene's broader genomic neighborhood.
- No specific trait associations, effect sizes, or p-values for this variant appear in the provided study data.
- Evidence for this variant's role in disease or complex traits is not documented in the available materials.
Key takeaways
- rs115417878 sits in the ARHGEF11 gene region.
- A 405,000-person UK Biobank GWAS using the Quickdraws method covered this gene's broader genomic neighborhood.
- No specific trait associations, effect sizes, or p-values for this variant appear in the provided study data.
- Evidence for this variant's role in disease or complex traits is not documented in the available materials.
What the research says A 2025 Nature Genetics study applied Quickdraws, a scalable variational inference GWAS method using a spike-and-slab prior on variant effects, to approximately 405,088 UK Biobank participants across 79 quantitative and 50 disease traits. Quickdraws identified 4.97% more quantitative-trait associations and 3.25% more disease-trait associations than REGENIE, and 22.71% and 7.07% more respectively than FastGWA. The provided study text does not include specific association results for rs115417878 or the ARHGEF11 locus.
Reported associations
- No specific associations documented: The provided study text does not report trait-specific findings for rs115417878. No effect sizes, odds ratios, or p-values for this variant appear in the available materials.
Evidence quality The sole provided study (Loya et al., Nature Genetics, 2025) is a methods paper introducing the Quickdraws GWAS algorithm, applied to n=405,088 UK Biobank samples covering 79 quantitative and 50 binary traits. The dataset is large and well-powered, and the authors note that replicated signals were observed in Biobank Japan and FinnGen. However, the provided text does not include variant-level association results for rs115417878. No PMID is listed for this study, and no additional studies covering this variant were provided. As a result, no replicated signals, p-values, or effect sizes for this specific variant can be reported from the available materials, and evidence for its specific associations must be considered absent from the provided study set.
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What is rs115417878?
rs115417878 is a single-nucleotide polymorphism (SNP), a common type of genetic variant, located in the ARHGEF11 gene region. Specific trait associations for this SNP are not reported in the currently available study data.
What does the ARHGEF11 gene do?
The provided studies do not describe the biological function of ARHGEF11. No gene-function details for this locus appear in the available study text.
What diseases or traits is rs115417878 linked to?
No specific disease or trait associations for rs115417878 are reported in the available study data. A large UK Biobank GWAS covered many traits but did not document results for this variant in the provided text.
What is a GWAS and how does it find genetic variants?
A genome-wide association study (GWAS) scans hundreds of thousands of genetic variants across many people to find statistical links between variants and traits. The provided study applied a new GWAS method called Quickdraws to about 405,000 UK Biobank participants, but specific findings for rs115417878 are not in the available text.
Is rs115417878 associated with any health conditions?
Based on the study data provided, no health condition associations for rs115417878 are documented. The available study focuses on GWAS methodology rather than reporting results for this specific variant.