rs115379007 (ADGRL2 / LINC01362): GWAS variant

Key takeaways

• rs115379007 is a variant near the ADGRL2 and LINC01362 genes, identified in a genome-wide association study of approximately 405,000 UK Biobank participants.
• It was detected using Quickdraws, a machine-learning-based GWAS method that finds around 5% more quantitative trait associations than the widely used REGENIE tool.
• The specific trait linked to this variant is not described in the available study excerpt.
• The Quickdraws analysis replicated its overall findings in Biobank Japan and FinnGen, lending credibility to the detection method.

What the research says A 2025 Nature Genetics study introduced Quickdraws, a scalable mixed-model association method (a statistical approach that accounts for genetic relatedness among participants) applied to 13.3 million variants across 79 quantitative and 50 binary traits in approximately 405,000 UK Biobank individuals. Quickdraws uses a spike-and-slab prior (a statistical model that assigns near-zero probability to most variant effects while allowing a small proportion to have detectable effects) combined with stochastic variational inference (a computational technique for efficiently approximating complex probability distributions) and GPU acceleration, identifying 4.97% more quantitative trait associations and 3.25% more disease trait associations than REGENIE. The variant rs115379007, near ADGRL2 and LINC01362 (referred to as "this locus" below), was among the associations identified; the specific phenotype and effect size for this locus are not reported in the available study excerpt.

Reported associations

• Phenotype not specified in available excerpt: This locus was identified as a novel association in the Quickdraws UK Biobank analysis of approximately 405,000 individuals; the specific associated trait and effect size are not detailed in the available study text.

Evidence quality The identifying study analyzed approximately 405,000 UK Biobank participants across 13.3 million variants, representing one of the largest GWAS cohorts applied to this question. Quickdraws was benchmarked against REGENIE, FastGWA, SAIGE, and BOLT-LMM, and its broader set of findings was replicated in Biobank Japan and FinnGen. However, the specific p-value, effect size, and phenotype for this locus are not reported in the available study excerpt, making variant-level evidence difficult to assess independently. This association should be treated as preliminary until full variant-level statistics are confirmed from the published results.

Lifestyle considerations No lifestyle considerations on file for this variant.