rs115368096 (OR10J8P): Blood Biomarker Variant
Key takeaways
- rs115368096 sits at OR10J8P, flagged in a large genome-wide scan of 35 blood and urine biomarkers in over 363,000 people
- The UK Biobank study included 363,228 individuals across multiple ancestry groups, with cross-validation against 42 independent cohorts
- 1,857 genetic loci were associated with at least one of 35 measured clinical lab traits in this study
- The specific biomarker and effect size for this variant are not detailed in the available study text
Key takeaways
- rs115368096 is a variant at OR10J8P (a locus in the olfactory receptor gene family), identified in a large genome-wide scan of 35 blood and urine biomarkers in over 363,000 people
- The UK Biobank study that surfaced this variant is one of the largest genetic analyses of clinical laboratory traits, spanning multiple ancestry groups
- The study found 1,857 loci associated with at least one of 35 measured biomarkers, with 3,374 fine-mapped association signals across the full dataset
- The particular biomarker linked to this variant and its effect size are not reported in the available study text
What the research says A genome-wide association study of 35 blood and urine biomarkers in the UK Biobank (n = 363,228 unrelated individuals) identified 1,857 loci that reached Bonferroni-corrected significance (p < 5 x 10^-9), including this locus. The study fine-mapped 3,374 association signals and cross-validated effect estimates against 42 independent published cohorts, finding high agreement across lipid, glycemic, kidney function, liver function, and other biomarker categories. The specific biomarker and effect size for rs115368096 are not stated in the available study excerpt.
Reported associations
- Blood or urine biomarker (specific trait not available in provided text): rs115368096 at this locus was identified in a GWAS of 35 clinical laboratory traits in the UK Biobank (n = 363,228); the precise biomarker, beta coefficient or odds ratio, and per-allele effect size are not stated in the provided study excerpt.
Evidence quality The association was detected in a large cohort (n = 363,228) using stringent Bonferroni-corrected thresholds (p < 5 x 10^-9 for imputed variants). The overall study methodology was validated against 42 external published cohorts, and polygenic risk scores built from identified loci improved disease stratification in an independent Finnish replication cohort (FinnGen, n = 135,500). However, the specific p-value, effect size, and replication record for rs115368096 in particular are absent from the provided study text, making a complete assessment of evidence strength for this variant impossible from available sources alone. Evidence for this locus should be treated as preliminary until full variant-level data are reviewed.
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What is OR10J8P?
OR10J8P is a locus in the olfactory receptor gene family. By naming convention, genes with an OR prefix belong to the olfactory receptor family, and a P suffix marks a pseudogene - a sequence that resembles a functional gene but typically does not produce a working protein.
Which study identified rs115368096?
rs115368096 was identified in a genome-wide association study of 35 blood and urine biomarkers in the UK Biobank, published in Nature Genetics in 2021. The study analyzed 363,228 participants and detected 1,857 loci associated with at least one biomarker.
Which blood or urine biomarker is rs115368096 linked to?
The specific biomarker associated with rs115368096 is not described in the available study text. The study covered 35 clinical lab measurements including kidney function markers, liver enzymes, lipids, and metabolic traits.
How reliable is the evidence for rs115368096?
The variant was found using strict statistical thresholds (Bonferroni-corrected p < 5 x 10^-9) in a cohort of 363,228 people, with effect estimates cross-validated against 42 independent published cohorts. Specific replication and effect-size data for this particular variant are not available in the provided study text.
Is rs115368096 related to disease risk?
The study that identified this variant focused on blood and urine biomarker levels rather than disease diagnoses directly. The study showed that polygenic scores built from identified biomarker loci improved stratification for conditions such as chronic kidney disease, type 2 diabetes, gout, and alcoholic cirrhosis, but no direct disease link for rs115368096 specifically is stated in the available text.