rs115343148 (ADAMTS8): UK Biobank GWAS Variant

Key takeaways

• This variant was identified in a UK Biobank genome-wide association scan of approximately 405,000 individuals using a new computational method called Quickdraws
• The locus sits near two genes: ADAMTS8 and ZBTB44-DT (a divergent transcript locus), though specific trait associations are not reported in the available study text
• Standard genome-wide association tools may have missed this variant; it was among the additional associations that Quickdraws discovered over competing methods
• Evidence for this locus comes from a single large-scale analysis; independent replication for this specific variant is not confirmed in the provided material

What the research says The sole study available for this variant describes Quickdraws, a genome-wide association (GWAS) method applied to 405,088 UK Biobank participants across 79 quantitative traits and 50 binary (disease) traits, scanning 13.3 million variants. Quickdraws identified 4.97% more quantitative-trait associations and 3.25% more binary-trait associations than REGENIE, a widely used competitor, with the overall set of additional associations showing replication signals in Biobank Japan and FinnGen cohorts. No specific effect sizes, p-values, or phenotype labels for rs115343148 at this locus appear in the provided study text, so the particular trait or traits this variant tags remain unspecified in the available evidence.

Reported associations

• UK Biobank GWAS finding: This variant was captured in a Quickdraws scan of 13.3 million variants across 79 quantitative and 50 binary traits in approximately 405,000 participants; the specific trait or traits it tags are not stated in the available study excerpt.

Evidence quality The single available study reports a large discovery cohort (n=405,088 UK Biobank participants), and the authors note that the broader set of newly identified associations showed replication signals in Biobank Japan and FinnGen. However, the provided text is a methods paper centered on the Quickdraws algorithm rather than a variant-specific report. No p-values, odds ratios, beta coefficients, or phenotype labels for this locus are given in the available excerpt, making the evidence base for this specific variant very limited. The association must therefore be considered preliminary until trait-specific results and independent replication are reported.

Lifestyle considerations No lifestyle considerations on file for this variant.