rs115257641 (PRKCE): No Reported Associations
Key takeaways
- No genome-wide significant association for rs115257641 appears in the provided research.
- The sole available study is a large childhood glioma GWAS identifying 9p21.3 (CDKN2B-AS1) as the first pediatric brain tumor risk locus.
- The primary associated variant in that study is rs573687 at CDKN2B-AS1, not rs115257641.
- No lifestyle, drug response, or tissue expression data for rs115257641 is available in the provided sources.
Key takeaways
- No genome-wide significant association for rs115257641 appears in the provided research.
- The sole available study is a large childhood glioma GWAS identifying 9p21.3 (CDKN2B-AS1) as the first pediatric brain tumor risk locus.
- The primary associated variant in that study is rs573687 at the CDKN2B-AS1 locus, not rs115257641.
- No lifestyle, drug response, or tissue expression data for rs115257641 is available in the provided sources.
What the research says The only study provided is a multi-ancestry meta-analysis of childhood glioma comprising 4,069 cases and 8,778 controls, which identified common variants in the CDKN2B-AS1 region at chromosomal band 9p21.3 as the first genome-wide significant risk locus for pediatric brain tumors. The lead associated variant was rs573687 (odds ratio 1.273, 95% confidence interval 1.179-1.374; p = 6.974×10^-¹^0), with the association driven specifically by low-grade astrocytoma (a slow-growing subtype of brain tumor); predicted decreased brain tissue expression of CDKN2B - a gene that suppresses tumor growth - was also significantly associated with astrocytoma (p = 8.090×10^-8). The variant rs115257641 and the PRKCE locus are not mentioned anywhere in the provided study text.
Reported associations
- Childhood low-grade astrocytoma: Genome-wide significant association reported for rs573687 at 9p21.3 (CDKN2B-AS1), OR 1.273 (95% CI 1.179-1.374), p = 6.974×10^-¹^0, in a meta-analysis of 4,069 pediatric glioma cases and 8,778 controls across multiple genetic ancestries; the association was replicated in an independent cohort. rs115257641 is not among the reported associated variants in the provided text.
- Childhood glioma overall: A separate variant, rs3731239 at the same 9p21.3 locus, approached genome-wide significance for glioma broadly (p = 5.411×10^-8); no significant association was observed for high-grade tumors. rs115257641 is not mentioned in this context.
Evidence quality The provided study is a well-powered, multi-ancestry meta-analysis (4,069 cases, 8,778 controls, spanning six genetic ancestries) with replication in an independent case-control cohort, yielding a genome-wide significant p-value for 9p21.3 variants in childhood astrocytoma. The transcriptome-wide association study and quantitative trait loci analyses provide a functional basis for the 9p21.3 association through CDKN2B expression. However, the provided text contains no data, association statistics, or mention of rs115257641 or the PRKCE locus; evidence quality for this variant specifically cannot be assessed from the available source material.
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What is rs115257641?
rs115257641 is a genetic variant located in the PRKCE gene. Based on the research provided, no specific trait associations for this variant have been reported in the available study text.
Is rs115257641 linked to brain tumors or glioma?
The one study provided examines childhood glioma, but its genome-wide significant findings involve a region called 9p21.3 (CDKN2B-AS1). The PRKCE locus, where rs115257641 is found, is not identified as a risk region in that study.
What variant was found to be associated with childhood glioma?
In the provided study, rs573687 at the CDKN2B-AS1 locus on chromosome 9 was significantly associated with childhood astrocytoma, with an odds ratio of 1.27 and a p-value of approximately 7×10^-¹^0. This is a distinct variant from rs115257641.
How strong is the evidence for rs115257641?
The provided research contains no association data for rs115257641 specifically. Its evidence quality cannot be assessed from the available source material.