Expressive

rs115231074 - HLA-DRB6 - HLA-DRB1

Magnitude 2.8 · 1 study on file

Reported associations

  • Polymorphisms in HLA Class II Genes Are Associated With Susceptibility to Staphylococcus aureus Infection in a White Population. - The Journal of infectious diseases (2016) · DeLorenze GN, Nelson CL, Scott WK, Allen AS, Ray GT, Tsai AL, Quesenberry CP, Fowler VG · PubMed 26450422

    Staphylococcus aureus can cause life-threatening infections. Human susceptibility to S. aureus infection may be influenced by host genetic variation. A genome-wide association study (GWAS) in a large health plan-based cohort included biologic specimens from 4701 culture-confirmed S. aureus cases and 45 344 matched controls; 584 535 single-nucleotide polymorphisms (SNPs) were genotyped on an array specific to individuals of European ancestry. Coverage was increased by imputation of >25 million common SNPs, using the 1000 Genomes Reference panel. In addition, human leukocyte antigen (HLA) serotypes were also imputed. Logistic regression analysis, performed under the assumption of an additive genetic model, revealed several imputed SNPs (eg, rs115231074: odds ratio [OR], 1.22 [P = 1.3 × 10(-

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • rs115231074 HLA-DRB1 S. aureus susceptibility Moderate

    HLA class II polymorphism associated with increased susceptibility to S. aureus skin and soft tissue infections

Lifestyle

  • Enhanced skin hygiene and wound care practices Low

    Increased S. aureus susceptibility suggests importance of barrier protection and prompt wound management

    Maintain regular skin hygiene, clean wounds promptly, avoid skin picking

Screening

  • S. aureus skin and soft tissue infection signs Moderate

    Genetic variant increases susceptibility to S. aureus infection, warranting enhanced vigilance for early signs

    Report any skin lesions, abscesses, or cellulitis promptly