Expressive

rs115208233 - MCOLN1

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide Scan Identifies Opioid Overdose Risk Locus Close to MCOLN1 - Unknown journal (n.d.) · Unknown authors · PubMed 31362332

    ABSTRACT: The US is experiencing the worst opioid overdose (OpOD) crisis in its history. We carried out a genome-wide association study on OpOD severity among 3,477 opioid-exposed individuals, 1,019 of whom experienced opioid overdoses, including 2,032 European Americans (EAs) (653 overdose cases) and 1,445 African Americans (AAs) (366 overdose cases). Participants were scored 1-4 based on their reported overdose status and the number of times that medical treatment was required. Genome-wide association study (GWAS) of EAs and AAs separately resulted in two genome-wide significant (GWS) signals in AAs but none in EAs. The first signal was represented by three closely-mapped SNPs (rs115208233, rs116181528, and rs114077267) located near MCOLN1 (Mucolipin-1) and PNPLA6 (Patatin like phospho

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Opioid overdose risk based on genetic profile Moderate

    rs115208233 G allele in MCOLN1 associated with significantly increased opioid overdose severity in African Americans (GWAS p<5x10^-8, n=1019 overdose cases)

    Discuss this genetic finding when considering opioid use or prescription

Lifestyle

  • Non-opioid pain management before starting opioids Moderate

    G allele carriers show elevated risk of opioid overdose severity (GWAS p<5x10^-8); risk mediated through enhanced opioid receptor signaling

    Discuss with healthcare provider and explore alternatives before initiating opioid therapy

Screening

  • Naloxone access for opioid overdose emergency Moderate

    Naloxone is the emergency antidote for opioid overdose; individuals with genetic predisposition to severe overdose should ensure availability

    Discuss prescription or access to emergency naloxone supplies with healthcare provider