rs11519272 - SLCO1B1: muscle pain and bile acid levels
Upload your raw genetic data once, we'll show you which variants you carry and what the research says.
Key takeaways
- This variant raises muscle pain risk with simvastatin.
- It also changes bile acid and fatty acid levels.
- The links are strong with very low p-values.
- Found in large genetic studies.
- No direct health impact beyond these traits.
Key takeaways
- This variant raises muscle pain risk with simvastatin.
- It also changes bile acid and fatty acid levels.
- The links are strong with very low p-values.
- Found in large genetic studies.
- No direct health impact beyond these traits.
What the research says This variant is associated with simvastatin-induced myopathy, a muscle pain condition, in about 2 thousand individuals. PMID 31220337 This variant also raises levels of taurodeoxycholic acid 3-sulfate and 1-arachidonoyl-GPE, with effect sizes reported as 0.45 and 0.27 respectively in about 7 thousand and 8 thousand individuals. PMID 36635386
Reported associations Simvastatin-induced myopathy This variant raises muscle pain risk when taking simvastatin with a reported effect size of 2.37 and p=3e-6 PMID 31220337 Taurodeoxycholic acid 3-sulfate levels This variant increases the level of this bile acid with a reported effect size of 0.45 and p=8e-100 PMID 36635386 1-arachidonoyl-GPE levels This variant raises the amount of this fatty acid with a reported effect size of 0.27 and p=1e-40 PMID 36635386
Evidence quality The association with simvastatin-induced myopathy was found in about 2 thousand individuals and has a very low p-value of 3e-6 [PMID 31220337]. The links to bile acid levels were observed in larger cohorts, around 7 thousand for taurodeoxycholic acid 3-sulfate (p=8e-100) and 8 thousand for 1-arachidonoyl-GPE (p=1e-40) [PMID 36635386]. No conflicting results were reported in the provided data.
No lifestyle considerations on file for this variant.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Drug interactions
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simvastatin-induced myopathy risk Moderate
SLCO1B1 encodes a hepatic transporter that affects statin metabolism; rs11519272 increases myopathy risk with simvastatin
if prescribed simvastatin, discuss with doctor about alternative statins
Frequently asked questions
What does rs11519272 do?
It is a genetic variant that increases muscle pain risk when taking simvastatin and raises certain bile acid levels.
Is this linked to heart disease?
The studies only show effects on muscle pain and bile acids, not heart disease.
Can I avoid the side effect?
You cannot change your genes; you can discuss with a doctor about alternative medications.