rs115157626 (GC/NPFFR2): UK Biobank GWAS Variant
Key takeaways
- rs115157626 is located in the GC-NPFFR2 gene region
- UK Biobank studies with up to approximately 405,000 participants provide the research context for this locus
- A 2021 study of 35 blood and urine biomarkers in 363,228 individuals identified 1,857 loci across the genome
- Specific trait associations and effect sizes for rs115157626 are not reported in the available study excerpts
Key takeaways
- rs115157626 is located in a chromosomal region containing the GC and NPFFR2 genes
- Large-scale UK Biobank genome-wide association studies involving up to approximately 405,000 participants provide the primary scientific context for this locus
- A 2021 UK Biobank study of 35 blood and urine biomarkers in 363,228 individuals identified 1,857 associated loci with 3,374 fine-mapped associations across the genome
- The provided study excerpts do not report specific trait associations or effect sizes for rs115157626 at this locus
What the research says A 2021 Nature Genetics study examined the genetic basis of 35 blood and urine laboratory measurements in 363,228 UK Biobank individuals, identifying 1,857 loci associated with at least one biomarker trait and 3,374 fine-mapped associations, with effect sizes validated against 42 independent cohorts. A 2025 Nature Genetics study introduced the Quickdraws algorithm, a genome-wide association method using a spike-and-slab prior and stochastic variational inference, and applied it to approximately 405,000 UK Biobank individuals across 79 quantitative and 50 binary traits, identifying 4.97% more associations than REGENIE and 22.71% more than FastGWA for quantitative traits. The specific associations and effect sizes for rs115157626 at the GC-NPFFR2 locus are not reported in the provided excerpts of either study.
Reported associations
- Blood and urine biomarkers: A 2021 Nature Genetics study of 35 biomarkers in 363,228 UK Biobank individuals identified 1,857 loci with Bonferroni-corrected significance (meta-analysis p<5x10^-9 for imputed variants); specific data for rs115157626 is not present in the provided text
- Quantitative and binary disease traits: A 2025 Nature Genetics application of the Quickdraws algorithm to approximately 405,000 UK Biobank individuals identified associations across 79 quantitative and 50 disease phenotypes; variant-level findings for rs115157626 are not included in the available text
Evidence quality The studies providing context for this locus used large UK Biobank cohorts (n=363,228 and approximately n=405,000). The 2021 biomarker study applied Bonferroni-corrected significance thresholds (meta-analysis p<5x10^-9 for imputed variants) and validated effect sizes against 42 previously published cohorts, with linkage disequilibrium Score regression intercepts ranging from 0.999 to 1.137 across all 35 biomarker phenotypes, indicating well-controlled population structure. The 2025 Quickdraws study replicated novel signals in two independent biobanks, FinnGen and Biobank Japan. Because neither provided study excerpt reports variant-level data for rs115157626, the specific evidence quality for this variant cannot be directly assessed from these sources; associations should be treated as preliminary and contextual pending access to full variant-level results.
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What genes is rs115157626 located near?
rs115157626 is located in a chromosomal region containing the GC and NPFFR2 genes.
What research has examined the GC-NPFFR2 region?
Large-scale UK Biobank genome-wide association studies have examined this region, including a 2021 study of 35 blood and urine biomarkers in 363,228 individuals and a 2025 study of 79 quantitative and 50 disease traits in approximately 405,000 individuals.
How large are the studies connected to rs115157626?
The studies providing research context for this locus used UK Biobank cohorts of 363,228 to approximately 405,000 participants, with findings replicated in independent cohorts including FinnGen and Biobank Japan.
What traits has rs115157626 been linked to?
The available study text does not report specific trait associations for rs115157626. The studies covering this genomic region examined blood and urine biomarkers, complex quantitative traits, and binary disease phenotypes in large UK Biobank samples.
How reliable is the evidence for variants in the GC-NPFFR2 region?
The UK Biobank studies covering this region used stringent significance thresholds and validated findings across multiple independent cohorts, but variant-specific evidence for rs115157626 is not present in the provided study text, so any associations should be treated as preliminary.