rs114830993 - PRICKLE2

Magnitude 2.0 · 1 study on file

Reported associations

• A multi-environments-gene interaction study of anxiety, depression and self-harm in the UK Biobank cohort. - Journal of psychiatric research (2022) · Li C, Liang X, Cheng S, Wen Y, Pan C, Zhang H, Chen Y, Zhang J, Zhang Z, Yang X, Meng P, Zhang F · PubMed 35026594

  The effects of gene-by-environment (G×E) interactions on complex diseases are significant, especially the superimposed effects of multiple environmental factors. However, research on the multi-environments-gene interactions of anxiety, depression, and self-harm is still limited. This study included white individuals (N = 66,041-74,482) from the UK Biobank. We fitted all environmental factors to a single environmental score (ES), and the estimated ES was used to calculate the multiplicative interaction effects between ES and genome-wide SNPs. Heritability was stratified by minor allele frequency (MAF) and linkage disequilibrium (LD). Our research found 10 loci with significant interaction effects, such as rs114830993 (PRICKLE2, P = 2.30 × 10 ), rs151323364 (ASTN2, P = 2.71 × 10

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