rs114703272 (ANKS1A): UK Biobank GWAS variant

Key takeaways

• This ANKS1A variant was identified in a large-scale GWAS of approximately 405,000 UK Biobank participants scanning 13.3 million genetic variants.
• The analysis used Quickdraws, a mixed-model association method that found more genetic associations than prior widely used methods in the same dataset.
• The specific trait linked to rs114703272 is not described in the available study excerpt.
• Overall study findings were replicated in Biobank Japan and FinnGen cohorts, though replication specific to this locus is not described in the available source.

What the research says A genome-wide association study (GWAS, a large scan of common genetic variants across the genome to detect links to traits or diseases) of approximately 405,000 UK Biobank participants analyzed 13.3 million variants across 79 quantitative and 50 binary traits using the Quickdraws mixed-model method. Quickdraws uses a spike-and-slab prior (a statistical model that assumes most variants have no effect while a smaller subset carry meaningful effects) and stochastic variational inference (an efficient computational approach for fitting complex statistical models to large datasets), and identified 4.97% more associations than REGENIE and 22.71% more than FastGWA for quantitative traits, and 3.25% and 7.07% more for binary traits respectively. The study reports that replicated signals from this analysis were found in Biobank Japan and FinnGen.

Reported associations

• UK Biobank trait (not specified in available text): rs114703272 was among variants identified in a GWAS of 79 quantitative and 50 binary traits in approximately 405,000 participants; the specific trait association for this locus is not described in the available study excerpt.

Evidence quality The available evidence comes from a single large-scale GWAS (Loya et al., Nature Genetics, 2025) of approximately 405,000 UK Biobank participants, covering 13.3 million variants across 79 quantitative and 50 binary traits. The study reports overall replication of its findings in Biobank Japan and FinnGen, but does not describe replication specific to this locus in the available text. No association statistics (such as a p-value, odds ratio, or beta coefficient, which measure how strongly a variant relates to a trait) specific to rs114703272 appear in the available study excerpt, making it not possible to assess evidence strength for this locus from the provided source alone. Evidence for this specific variant should be considered preliminary and incomplete pending additional published data.

Lifestyle considerations No lifestyle considerations on file for this variant.