rs114655816 HLA-DQA1 strep and triglycerides
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Key takeaways
- This variant is linked to higher strep infection risk.
- It is also linked to slightly higher triglyceride values.
- Both findings are from genome-wide association studies.
Key takeaways This variant is linked to higher strep infection risk. It is also linked to slightly higher triglyceride values. Both findings are from genome-wide association studies.
What the research says This variant is associated with strep seropositivity with a reported effect size of 5.51 p=4e-8 in about 1 thousand individuals [37164013]. It is also linked to higher triglyceride levels with an effect size of 0.054 p=4e-41 in about 394 thousand individuals [39789286].
Reported associations Seropositivity for streptococcus pneumoniae peptide: the variant is associated with higher strep infection risk a reported effect size of 5.51 p=4e-8 in about 1 thousand individuals [37164013]. Triglyceride levels: the variant is linked to slightly higher triglyceride values a reported effect size of 0.054 p=4e-41 in about 394 thousand individuals [39789286].
Evidence quality The evidence comes from two genome-wide association studies each with large samples one of about 1000 individuals the other of about 394 thousand individuals both report significant associations with low p values and no contradictory results [37164013][39789286].
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What does the rs114655816 variant do?
The variant is associated with a small increase in strep infection risk and a modest rise in triglyceride levels according to genome-wide association studies.
Is this variant related to disease?
No, the associations are modest and not enough to cause disease. They reflect statistical links rather than clinical impact.
Can I change my diet because of this variant?
There is no evidence that the variant requires any dietary changes; it only shows a small link to higher triglycerides.