Expressive

rs113848006 (PI16): UK Biobank GWAS Variant

Key takeaways

  • rs113848006 is a variant near the PI16 gene identified in a UK Biobank genome-wide study of approximately 405,000 people.
  • The study analyzed 79 quantitative and 50 binary traits across more than 13 million genetic variants.
  • The available study text describes the GWAS methodology but does not report specific trait associations or effect sizes for this variant.
  • No phenotype-specific findings for this variant are present in the available research.

Key takeaways

  • rs113848006 is a genetic variant located near the PI16 gene, examined in a large-scale UK Biobank genome-wide association study of approximately 405,000 individuals.
  • The study analyzed 79 quantitative and 50 binary traits across more than 13.3 million genetic variants.
  • The available study text describes the GWAS methodology used to identify this variant but does not report specific trait associations or effect sizes for this variant.
  • No odds ratios, beta coefficients, or p-values for rs113848006 are present in the provided study text; the strength of evidence for any specific association cannot be assessed from the available material.

What the research says rs113848006, near the PI16 gene, was examined in a UK Biobank genome-wide association study that applied the Quickdraws mixed-model algorithm to approximately 405,088 participants across 79 quantitative and 50 binary traits using 13.3 million variants. The source study reports that Quickdraws identified 4.97% more quantitative trait associations and 3.25% more binary trait associations than the REGENIE method across the full UK Biobank analysis, with overall replication gains observed in Biobank Japan and FinnGen, but it does not enumerate individual variant results or describe specific phenotypic associations for this variant.

Reported associations

  • No variant-specific trait associations reported: The available study text does not list phenotypic associations for rs113848006. The source study reports aggregate discovery gains across the full UK Biobank analysis but does not describe findings for individual variants.

Evidence quality The source study applied Quickdraws to approximately 405,088 UK Biobank samples, covering 13.3 million variants across more than 100 traits, and assessed replication signals in Biobank Japan and FinnGen. No variant-level data, p-values, odds ratios, or effect sizes for rs113848006 appear in the provided study text. The study focuses on the performance of the Quickdraws algorithm relative to REGENIE, FastGWA, BOLT-LMM, and SAIGE rather than reporting per-variant findings. Evidence for any specific association of this variant is therefore indeterminate from the available material.

Lifestyle considerations No lifestyle considerations on file for this variant.

Frequently asked questions

What is rs113848006?

rs113848006 is a genetic variant located near the PI16 gene. It was examined in a large-scale genome-wide association study of approximately 405,000 UK Biobank participants, though specific trait associations for this variant are not described in the available research.

What traits is rs113848006 linked to?

The available study text does not report specific trait associations for this variant. The source study covers 79 quantitative and 50 binary traits across the UK Biobank but does not enumerate results for individual variants.

How large was the study that examined this variant?

The genome-wide association study applied the Quickdraws method to approximately 405,088 UK Biobank participants, analyzing over 13.3 million genetic variants across more than 100 traits.

What is the PI16 gene?

The available study does not describe the biological function of PI16. The source study focuses on the statistical methodology used for genome-wide association testing rather than characterizing individual genes.

Was this variant replicated in other populations?

The source study reports that overall association signals found by the Quickdraws method showed replication gains in Biobank Japan and FinnGen, but variant-specific replication results for rs113848006 are not described in the available text.