Expressive

rs113435421 (OSTC - ETNPPL): Variant Overview

Key takeaways

  • No disease or trait associations for rs113435421 were found in the provided research studies.
  • This variant is located in the OSTC-ETNPPL gene region but no function or trait link was reported in available sources.
  • Without relevant study data, evidence quality for this variant cannot be assessed.
  • The one study provided focused on a separate genomic locus linked to childhood brain tumors.

Key takeaways

  • No disease or trait associations for rs113435421 were found in the provided research studies.
  • This variant is located in the OSTC-ETNPPL gene region but no function or trait link was reported in available sources.
  • Without relevant study data, evidence quality for this variant cannot be assessed.
  • The one study provided focused on a separate genomic locus linked to childhood brain tumors, not this region.

What the research says The only study included in the provided materials is a multi-ancestry GWAS meta-analysis of 4,069 children with glioma and 8,778 controls; it identified common variants in CDKN2B-AS1 at 9p21.3 as the first genome-wide significant common-variant locus for childhood astrocytoma (rs573687, OR 1.273, 95% CI 1.179-1.374, p = 6.974e-10), with the association driven by low-grade astrocytoma. This study does not discuss rs113435421 or the OSTC-ETNPPL region at any point.

Reported associations

  • OSTC-ETNPPL locus (rs113435421): No associations were reported in the provided studies.

Evidence quality No evidence directly relevant to rs113435421 is present in the provided research materials. The available GWAS examined childhood glioma susceptibility across 4,069 cases and 8,778 controls of multiple genetic ancestries and identified a significant association at 9p21.3 (CDKN2B-AS1), but the OSTC-ETNPPL region was not investigated or mentioned. Without dedicated study data, the evidence base for this variant is absent from the provided sources.

Lifestyle considerations No lifestyle considerations on file for this variant.

Frequently asked questions

What is rs113435421?

rs113435421 is a genetic variant annotated to the OSTC-ETNPPL gene region. No disease or trait associations for this specific variant were reported in the provided research.

What genes are near rs113435421?

The variant is located in the region containing the OSTC and ETNPPL genes, though the provided studies do not describe the role these genes play in relation to this variant.

Is rs113435421 linked to any diseases or traits?

No disease or trait associations for rs113435421 were reported in the research studies provided. The evidence base for this variant is absent from the available sources.