Expressive

rs113401670 (WDR72 / LINC02490): Blood Biomarker GWAS

Key takeaways

  • rs113401670 sits near two genes: LINC02490 (a non-coding RNA) and WDR72 (a protein-coding gene with WD repeat structural domains)
  • It was identified in one of the largest biomarker genetics studies to date, covering 35 blood and urine traits in 363,228 UK Biobank participants
  • The study found 1,857 loci in total with 3,374 fine-mapped associations, placing this variant within a broadly characterised genetic landscape for clinical lab values
  • The specific biomarker trait linked to this locus is not stated in the available study excerpt, limiting interpretation of its functional significance

Key takeaways

  • rs113401670 sits in a genomic region spanning LINC02490 (a long intergenic non-coding RNA, meaning DNA that is read into RNA but not translated into protein) and WDR72 (WD repeat domain 72, a protein-coding gene)
  • This variant was catalogued in a large genome-wide association study (GWAS, a scan of hundreds of thousands of genetic sites across the genome) of 35 clinical blood and urine laboratory measurements in the UK Biobank (n=363,228)
  • The specific biomarker associated with this locus is not detailed in the available study text
  • Evidence comes from a single large-scale study; independent replication specific to rs113401670 is not described in the available excerpt

What the research says A GWAS of 35 blood and urine laboratory measurements in the UK Biobank (n=363,228) identified 1,857 loci associated with at least one biomarker trait, with 3,374 fine-mapped associations across coding, regulatory, and structural variant categories. The rs113401670 variant at this locus was among the variants assessed in this systematic analysis, though the specific biomarker trait and effect size for this locus are not stated in the available text. The study applied a Bonferroni-corrected significance threshold of p < 5 x 10^-9 for imputed variants.

Reported associations

  • Blood or urine biomarker (UK Biobank GWAS, n=363,228): This locus was flagged in a genome-wide study of 35 clinical laboratory traits; the specific trait for this locus is not named in the available study text.

Evidence quality Evidence for rs113401670 derives from a single large-scale GWAS in the UK Biobank (n=363,228), with results evaluated against an independent Finnish cohort (FinnGen, n=135,500). The study used a strict Bonferroni-corrected p-value threshold (p < 5 x 10^-9 for imputed variants) and fine-mapped 3,374 associations across 1,857 loci. Specific p-values and effect sizes for this locus are not reported in the available text. Independent replication specific to rs113401670 is not described in the available excerpt, making evidence strength difficult to assess fully.

Lifestyle considerations No lifestyle considerations on file for this variant.

Frequently asked questions

What is the WDR72 gene?

WDR72 (WD repeat domain 72) is a protein-coding gene located in the same genomic region as rs113401670. WD repeat domains are recurring structural protein motifs; the specific role of WDR72 in clinical biomarker biology is not described in the available study text.

What is LINC02490?

LINC02490 is a long intergenic non-coding RNA, meaning it is a segment of DNA that is transcribed into RNA but does not produce a protein. Its relationship to the rs113401670 association signal is not specified in the available study data.

Which blood or urine biomarker is rs113401670 associated with?

rs113401670 was identified in a genome-wide study of 35 blood and urine biomarkers in the UK Biobank, but the specific trait for this locus is not described in the available text from that study.

How reliable is the evidence for rs113401670?

The variant was detected in a large study of 363,228 UK Biobank participants using a strict significance threshold, with findings evaluated against an independent Finnish cohort of 135,500 people. However, the specific effect size and independent replication for this locus are not detailed in the available study excerpt, so the strength of evidence for this particular variant cannot be fully assessed.

How large was the study that found this variant?

The genome-wide study that identified this variant analysed 363,228 individuals in the UK Biobank and evaluated findings in an independent Finnish cohort (FinnGen) of 135,500 participants.