rs1133152 - TMEM161B

Magnitude 2.2 · 1 study on file

Reported associations

• Common variants on 6q16.2, 12q24.31 and 16p13.3 are associated with major depressive disorder. - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (2019) · Li X, Luo Z, Gu C, Hall LS, McIntosh AM, Zeng Y, Porteous DJ, Hayward C, Li M, Yao YG, Zhang C, Luo XJ · PubMed 29728651

  Accumulating evidence suggests that genetic factors have a role in major depressive disorder (MDD). However, only limited MDD risk loci have been identified so far. Here we perform a meta-analysis (a total of 90,150 MDD cases and 246,603 controls) through combing three genome-wide association studies of MDD, including 23andMe (cases were self-reported with a clinical diagnosis or treatment of depression), CONVERGE (cases were diagnosed using the Composite International Diagnostic Interview) and PGC (cases were diagnosed using direct structured diagnostic interview (by trained interviewers) or clinician-administered DSM-IV checklists). Genetic variants from two previously unreported loci (rs10457592 on 6q16.2 and rs2004910 on 12q24.31) showed significant associations with MDD (P < 5 

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