rs10457592 - FBXL4 - MIR548AI

Magnitude 2.2 · 1 study on file

Reported associations

• Identification of 15 genetic loci associated with risk of major depression in individuals of European descent - Unknown journal (n.d.) · Unknown authors · PubMed 27479909

  ABSTRACT: Despite strong evidence supporting the heritability of Major Depressive Disorder, previous genome-wide studies were unable to identify risk loci among individuals of European descent. We used self-reported data from 75,607 individuals reporting clinical diagnosis of depression and 231,747 reporting no history of depression through 23andMe, and meta-analyzed these results with published MDD GWAS results. We identified five independent variants from four regions associated with self-report of clinical diagnosis or treatment for depression. Loci with pval<1.0×10−5 in the meta-analysis were further analyzed in a replication dataset (45,773 cases and 106,354 controls) from 23andMe. A total of 17 independent SNPs from 15 regions reached genome-wide significance after joint-analysis

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