Expressive

rs1130420 (HLA-DQB1): GWAS-Identified Variant

Key takeaways

  • rs1130420 is located in the HLA-DQB1-AS1 and HLA-DQB1 gene region
  • It was identified in a GWAS of approximately 405,000 UK Biobank participants analyzing 13.3 million variants
  • The study analyzed 79 quantitative and 50 binary traits, with replicated signals in Biobank Japan and FinnGen
  • Specific trait associations for rs1130420 are not detailed in the available research text

Key takeaways

  • rs1130420 is a genetic variant located in the HLA-DQB1-AS1 and HLA-DQB1 gene region.
  • It was identified in a large-scale GWAS (genome-wide association study, a method that scans the genome for variants linked to traits) of approximately 405,000 UK Biobank participants.
  • The GWAS that identified this variant analyzed 13.3 million variants across 79 quantitative and 50 binary traits.
  • Specific trait associations and effect sizes for rs1130420 are not detailed in the available study text.

What the research says rs1130420 was identified using the Quickdraws algorithm, a GWAS method that applies a spike-and-slab prior (a statistical model that distinguishes variants with large effects from those with negligible effects) to approximately 405,088 UK Biobank samples across 13.3 million variants. Quickdraws identified 4.97% more quantitative trait associations and 3.25% more binary trait associations than REGENIE, a widely used GWAS benchmark, with replicated signals validated in Biobank Japan and FinnGen cohorts. The available study text does not report the specific trait associations or effect sizes attributed to rs1130420.

Reported associations

  • No variant-specific associations reported: The available study text does not include specific trait associations, odds ratios, or effect sizes for rs1130420. The study describes the Quickdraws method broadly applied to UK Biobank data across 79 quantitative and 50 binary traits, but individual variant-level results for this locus are not provided in the excerpt.

Evidence quality The study analyzed approximately 405,088 UK Biobank participants across 79 quantitative and 50 binary traits with 13.3 million variants, representing a large and well-powered dataset. Associations identified by Quickdraws were validated using Biobank Japan and FinnGen replication cohorts. No PMID is available for this study in the provided metadata, limiting direct lookup of supplemental results. The evidence specifically attributable to rs1130420 from this source is limited because the available study text does not report variant-level statistics for this locus.

Lifestyle considerations No lifestyle considerations on file for this variant.

Frequently asked questions

What is rs1130420?

rs1130420 is a genetic variant located in the HLA-DQB1-AS1 and HLA-DQB1 gene region. It was flagged in a large-scale scan of genetic variants across approximately 405,000 UK Biobank participants.

What gene is rs1130420 associated with?

rs1130420 is associated with the HLA-DQB1-AS1 and HLA-DQB1 genes. These gene names are reported as part of the variant's chromosomal location identifier.

What traits is rs1130420 linked to?

The available research does not detail specific trait associations for rs1130420. It was identified in a GWAS of about 405,000 UK Biobank participants, but the study excerpt does not provide the specific phenotypes (measurable characteristics) linked to this variant.

How was rs1130420 discovered?

rs1130420 was identified using Quickdraws, a genome-wide association study algorithm that uses a spike-and-slab statistical model to improve detection of genetic associations. The study analyzed 13.3 million variants in approximately 405,000 UK Biobank participants across 79 quantitative and 50 binary traits.