Expressive

rs11263654 (LINC02956-LINC02953): Evidence Review

Key takeaways

  • rs11263654 is located in the LINC02956-LINC02953 genomic region.
  • No trait or disease associations have been reported for this variant in the available research.
  • The single study in this evidence base examined a different variant and chromosomal locus entirely.
  • No lifestyle recommendations can be drawn from the current evidence.

Key takeaways

  • No associations have been reported for rs11263654 in the provided study literature.
  • The single study in this evidence base investigated a different variant and chromosomal locus and does not examine this SNP.
  • No effect sizes, trait associations, or clinical annotations are available for this variant from the provided sources.
  • Lifestyle or supplementation guidance cannot be derived from the current evidence base.

What the research says The sole study in the provided evidence base is a meta-analysis of genome-wide association studies (GWAS - large scans of the genome for variants statistically linked to a trait) investigating risk loci for renal cell carcinoma (a type of kidney cancer affecting adults). It examined the 1q24.1 chromosomal region and the variant rs3845536 near the ALDH9A1 gene; rs11263654 and the LINC02956-LINC02953 locus are not mentioned or examined anywhere in this study.

Reported associations

  • No associations with rs11263654 are reported in the provided literature.

Evidence quality No evidence specific to rs11263654 is present in the provided study literature. The single study available is a meta-analysis of renal cell carcinoma risk (2,215 cases and 8,566 controls, with replication in 383 cases and 2,189 controls from TCGA, and a further evaluation in 2,461 cases and 5,081 controls from IARC) and concerns an entirely separate genomic variant at a different chromosomal locus; it cannot be used to characterize rs11263654.

Lifestyle considerations No lifestyle considerations on file for this variant.

Frequently asked questions

What is rs11263654?

rs11263654 is a genetic variant located in the LINC02956-LINC02953 genomic region. No trait or disease associations have been established for this variant in the available published literature.

Is rs11263654 associated with any disease?

No disease or trait associations have been reported for rs11263654 in the study literature available for this entry.

What are LINC02956 and LINC02953?

LINC02956 and LINC02953 are the genomic loci in whose region rs11263654 resides. Their specific biological functions are not described in the study literature available for this entry.