Expressive

rs11246130 (IFITM3-AS1/B4GALNT4): GWAS Variant

Key takeaways

  • rs11246130 sits near IFITM3-AS1 and B4GALNT4 and was captured in a GWAS of approximately 405,000 UK Biobank participants.
  • The study used Quickdraws, a new algorithm that found 4.97% to 22.71% more associations than leading existing methods.
  • Specific trait associations and effect sizes for this variant are not reported in the available study text.
  • No independent replication is confirmed for this specific variant in the provided sources.

Key takeaways

  • rs11246130 sits near the IFITM3-AS1 and B4GALNT4 genes and was captured in a genome-wide association study (GWAS) of approximately 405,000 UK Biobank participants.
  • The study used Quickdraws, a new GWAS algorithm that found 4.97% to 22.71% more associations than widely used existing methods.
  • Specific trait associations and effect sizes for this variant are not reported in the available study text.
  • No independent replication data are confirmed for this specific variant in the provided sources.

What the research says A genome-wide association study applied the Quickdraws algorithm, a machine-learning-based method that uses a spike-and-slab prior (a statistical model allowing for both negligible and meaningful genetic effects) together with stochastic variational inference (a scalable approximation technique that makes large-scale Bayesian analysis computationally practical), to approximately 405,088 UK Biobank individuals analyzing 79 quantitative and 50 binary traits. Quickdraws identified 4.97% more quantitative-trait associations than REGENIE and 22.71% more than FastGWA, and 3.25% and 7.07% more binary-trait associations respectively, at comparable computational cost. The specific trait associations for this locus are not detailed in the available study text.

Reported associations

  • Large-scale multi-trait GWAS discovery: This locus was detected among approximately 405,088 UK Biobank participants across 79 quantitative and 50 binary traits; the particular trait or traits driving the association at rs11246130 are not named in the provided study text.

Evidence quality The source study involved approximately 405,088 UK Biobank participants analyzed across 129 combined traits. Quickdraws demonstrated higher statistical power than REGENIE (4.97% more quantitative-trait hits, 3.25% more binary-trait hits) and FastGWA (22.71% and 7.07% more, respectively). The study notes replicated signals in independent cohorts including Biobank Japan and FinnGen, though whether this specific variant was among those replicated signals is not stated in the provided text. Specific p-values and effect sizes for rs11246130 are not available in the excerpt provided. Given the absence of variant-level detail and independent replication confirmation, evidence for this specific locus should be treated as preliminary.

Lifestyle considerations No lifestyle considerations on file for this variant.

Frequently asked questions

What is rs11246130?

rs11246130 is a genetic variant located near the IFITM3-AS1 and B4GALNT4 genes. It was flagged in a large genome-wide association study of approximately 405,000 UK Biobank participants using a high-powered GWAS algorithm called Quickdraws.

What traits is rs11246130 associated with?

Specific trait associations for rs11246130 are not detailed in the available study text. The variant was identified within a large multi-trait GWAS covering 79 quantitative and 50 binary traits, but the particular trait driving the association is not named in the provided excerpt.

How large was the study that identified rs11246130?

The study analyzed approximately 405,088 UK Biobank participants across 79 quantitative and 50 binary traits using Quickdraws, a machine-learning-based GWAS algorithm designed to detect more associations than existing tools at comparable computational cost.

Was rs11246130 replicated in independent cohorts?

The study reports replicated signals in Biobank Japan and FinnGen, but the provided text does not confirm whether rs11246130 specifically was among the replicated variants. Evidence for this locus should be considered preliminary.

What is the Quickdraws method used to find this variant?

Quickdraws is a GWAS algorithm that uses a spike-and-slab statistical prior and a machine-learning technique called stochastic variational inference to detect genetic associations with higher power than standard methods, while remaining practical to run on large biobank datasets.