rs11244883 (ADAM12): Metabolic QTL in Elite Athletes
Key takeaways
- rs11244883 sits near the ADAM12 gene and was identified in a metabolomics genome-wide study of elite athletes.
- The study examined 275,016 genetic variants and 751 serum metabolites in 490 elite athletes.
- This variant is classified as a metabolic QTL, meaning it may influence levels of specific metabolites in blood.
- Evidence comes from a single study with no independent replication reported in the available data.
- Specific effect sizes and the metabolite target for rs11244883 were not detailed in the available study text.
Key takeaways
- rs11244883 is a genetic variant located in or near the ADAM12 gene, identified through a metabolic genome-wide association study of elite athletes.
- The source study examined 275,016 genetic variants alongside 751 serum metabolites in 490 elite athletes, searching for variants that influence metabolite levels.
- This type of finding is called a metabolic quantitative trait locus, or mQTL: a genetic variant associated with the level of a specific metabolite in the body.
- Evidence for rs11244883 comes from a single study; no independent replication was reported in the provided data.
- Specific effect sizes and the metabolite target for this variant were not detailed in the available study text.
What the research says rs11244883 is located in or near the ADAM12 gene and was identified as a candidate mQTL in a metabolic genome-wide association study of 490 elite athletes. The study profiled 751 serum metabolites alongside 275,016 common genetic variants, with the aim of finding genetically-influenced metabolites that differentiate elite from non-elite athletes and that relate to endurance performance. The highlighted novel findings in the study involved other loci - specifically FOLH1, VNN1, and SULT2A1 - and the precise metabolite associated with rs11244883 along with any specific effect sizes were not presented in the available text.
Reported associations
- Athletic performance / metabolomics: rs11244883 was identified in an mGWAS of 490 elite athletes as a candidate metabolic quantitative trait locus; the specific associated metabolite and effect size were not detailed in the provided study text.
Evidence quality Evidence for rs11244883 comes from one metabolic GWAS conducted in 490 elite athletes across 275,016 genotyped SNPs and 751 serum metabolites. No independent replication of this variant was reported, and specific statistical values such as p-values, odds ratios, or beta coefficients for rs11244883 were not present in the provided text excerpt. The study authors noted that genetic research on athletic performance has been constrained by small sample sizes and the complex nature of performance as a phenotype. Findings should be treated as preliminary in the absence of replication.
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What is rs11244883?
rs11244883 is a single nucleotide polymorphism - a common type of genetic variant - located in or near the ADAM12 gene. It was identified as a candidate metabolic quantitative trait locus in a genome-wide study of elite athletes.
What is a metabolic QTL and why does it matter?
A metabolic quantitative trait locus, or mQTL, is a genetic variant associated with the level of a specific metabolite in the body. The source study identified mQTLs by combining genetic data with high-resolution profiling of 751 serum metabolites in 490 elite athletes, aiming to link genetic differences to measurable biochemical traits.
Is rs11244883 linked to athletic performance?
It was identified in a metabolomics genome-wide association study of 490 elite athletes, but the specific metabolite it influences and any direct connection to performance outcomes were not detailed in the available study text. The evidence is preliminary and based on one study with no reported replication.
How strong is the evidence for rs11244883?
Evidence is preliminary. It comes from a single study of 490 elite athletes with no reported independent replication. Specific p-values and effect sizes for this variant were not available in the provided study text.