rs11228623 - OR5M8 - OR5M7P

Magnitude 2.0 · 1 study on file

Reported associations

• Genome-wide association study meta-analysis uncovers novel genetic variants associated with olfactory dysfunction - BMC genomic data (2025) · Imtiaz MA, Melas K, Tin A, Talevi V, Chen H, Fornage M, Shrestha S, Gögele M, Emmert D, Pattaro C, Pramstaller P, Förster F, Horn K, Mosley TH, Fuchsberger C, Scholz M, Breteler MMB, Aziz NA · PubMed 40963118

  ABSTRACT: Background Olfactory dysfunction is among the earliest signs of many age-related neurodegenerative diseases and has been associated with increased mortality in older adults; however, its genetic basis remains largely unknown. Therefore, here we aimed to elucidate its genetic architecture through a genome-wide association study meta-analysis (GWMA). Methods This GWMA included the participants of European ancestry (N = 22,730) enrolled in four different large population-based studies followed by a multi-ancestry GWMA including participants of African ancestry (N = 1,030). Olfactory dysfunction was assessed using a 12-item smell identification test. Results GWMA revealed a novel genome-wide significant locus (tagged by single nucleotide polymorphism rs11228623 at the 11q12 l

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