rs112279447 - BRK1

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association study identifies loci for arterial stiffness index in 127,121 UK Biobank participants - Unknown journal (n.d.) · Unknown authors · PubMed 31235810

  ABSTRACT: Arterial stiffness index (ASI) is a non-invasive measure of arterial stiffness using infra-red finger sensors (photoplethysmography). It is a well-suited measure for large populations as it is relatively inexpensive to perform, and data can be acquired within seconds. These features raise interest in using ASI as a tool to estimate cardiovascular disease risk as prior work demonstrates increased arterial stiffness is associated with elevated systolic blood pressure, and ASI is predictive of cardiovascular disease and mortality. We conducted genome-wide association studies (GWASs) for ASI in 127,121 UK Biobank participants of European-ancestry. Our primary analyses identified variants at four loci reaching genome-wide significance (P < 5 × 10−8): TEX41 (rs1006923; P =

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